FIGURE

Figure 1

ID

ZDB-FIG-190723-1638

Publication

Lee et al., 2015 - Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos

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Figure 1

Global features of DNA methylation across zebrafish embryogenesis

(a) A schematic representation of the study. MeDIP-seq and MRE-seq libraries were constructed from genomic DNA of six developmental stages: sperm, 2.5 hpf, 3.5 hpf, 4.5 hpf, 6 hpf and 24 hpf. Stage-specific drawings of representative embryos are adapted from ref ²⁶ with permission from Wiley-Liss, Inc. © 1995. The two sequencing libraries for each developmental stage were further processed and analyzed using recently developed algorithms, methylCRF and M&M. Both algorithms integrate MeDIP-seq and MRE-seq data. (b–d) The average DNA methylation level across different genomic features: gene-associated regions (b), CpG islands and neighboring regions (c), and high and low CpG density promoters (d). Promoter was defined as 1 kb upstream from TSS in (b). CpG island shore was defined as 2 kb regions flanking a CpG island, and CpG shelf as a 2 kb region outside a CpG shore (away from the CGI). The average CpG densities (grey lines) over the regions was also plotted in (b) and (d).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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