FIGURE

Fig. S10

ID

ZDB-FIG-180516-27

Publication

Ojeda Naharros et al., 2017 - Loss-of-function of the ciliopathy protein Cc2d2a disorganizes the vesicle fusion machinery at the periciliary membrane and indirectly affects Rab8-trafficking in zebrafish photoreceptors

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Fig. S10

SNAP25 mislocalizes in OSs and accumulated vesicles of cc2d2a-/- PRs at 3 dpf.

(A) 3 dpf correlative light and electron microscopy (CLEM) image of a cc2d2a-/- retina stained with anti-SNAP25 (green) and DAPI (blue, nuclei). (B-C’) Higher magnification images of the boxed regions in (A). SNAP25 mislocalizes in misshapen outer segments (B) and accumulated vesicles (C). (B’ and C’) are SEM images only of (B and C). Arrows point to vesicular structures where SNAP25 mislocalizes. Scale bars: 4 μm in A and 1 μm in B-C’. OS outer segment, m mitochondria, N nucleus, P pigment, v vesicular structures.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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