FIGURE

Fig. 3

ID

ZDB-FIG-170428-28

Publication

El-Rass et al., 2017 - Disruption of pdgfra alters endocardial and myocardial fusion during zebrafish cardiac assembly.

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

Pdgfra homozygous mutants exhibit abnormal cardiac phenotypes. An incross of the pdgfra gene-trapped strain carrying a Tg(cmlc2:EGFP) transgene was used to investigate the cardiac phenotype. (A) At 48 hpf, mild and severe −/− mutants present with abnormal cardiac looping; severe −/− embryos also develop an enlarged atrium and pericardial edema. (B) At 96 hpf, the hearts of mild −/− mutants remain incompletely looped, while severe −/− mutants present with collapsed chambers and pericardial edema. Arrows pointing at ventricle (V) and atrium (A). The fish cranium is on the left. Scale bar: 100 μm.

Expression Data

Gene:	EGFP
Fish:	twu34Tg pdgfra^{smh1300Gt/smh1300Gt}; twu34Tg
Anatomical Term:	cardiac muscle cell
Stage Range:	Long-pec to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pdgfra^{smh1300Gt/smh1300Gt}; twu34Tg
Observed In:	atrium heart heart looping pericardium
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biol. Open