FIGURE

Fig. S3

ID

ZDB-FIG-161122-36

Publication

Modzelewska et al., 2016 - MEK Inhibitors Reverse Growth of Embryonal Brain Tumors Derived from Oligoneural Precursor Cells

Other Figures

All Figure Page

Back to All Figure Page

Fig. S3

MEK inhibitors prevent growth of tumors in an embryonic transplantation assay. Related to Figure 4. (A) Representative images of embryos at 24 hours post transplantation before treatment (3 dpf) and embryos that have been treated for five days (8 dpf) with DMSO control or 50 μM MEK inhibitor U0126. (B) Quantification of immunofluorescence on the final day of treatment (8 dpf) shows a significant decrease in the transplanted tumor mass in U0126-treated embryos compared to control. (C) Analysis of embryo survival during treatment (3-8 dpf) with DMSO and U0126 shows that both treatments are well tolerated during this stage of development. Averages in (B-C) represent two independent experiments (+/-SEM).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.