FIGURE

Fig. 2

ID

ZDB-FIG-150609-16

Publication

Bührdel et al., 2015 - In vivo characterization of human myofibrillar myopathy genes in zebrafish

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Fig. 2

Loss of MFM gene function results in a progressive motility deficiency (A–C) Spontaneous movement assay with false-colored superimposed overviews of 24 hpf control (A) and MFM morphants (B–C); Red pictures = 0 s; green pictures = 10 s. (D) Summary of voluntary movement at 24 hpf of MFM morphants. (E) Quantification of flight reaction to a touch stimulus of 72 hpf individuals. Darker gray bars indicate the effect of Morpholinos directed against non-MFM genes as controls. Asterisks indicate significance compared to the MO-control group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-cryaba WT + MO1-cryabb WT + MO1-dnajb6a WT + MO1-dnajb6b WT + MO1-fhl1b WT + MO1-ldb3a WT + MO1-myot WT + MO1-plcg1 WT + MO1-pleca WT + MO1-plecb WT + MO2-bag3 WT + MO2-cmlc1 WT + MO2-desma WT + MO2-flnca WT + MO3-desmb WT + MO3-fhl1a WT + MO3-vcp WT + MO4-flncb (all 18)
Knockdown Reagents:	MO1-cryaba MO1-cryabb MO1-dnajb6a MO1-dnajb6b MO1-fhl1b MO1-ldb3a MO1-myot MO1-plcg1 MO1-pleca MO1-plecb MO2-bag3 MO2-cmlc1 MO2-desma MO2-flnca MO3-desmb MO3-fhl1a MO3-vcp MO4-flncb (all 18)
Observed In:	locomotion thigmotaxis whole organism
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biochem. Biophys. Res. Commun.