FIGURE

Fig. S1

ID

ZDB-FIG-130411-7

Publication

Boglev et al., 2013 - Autophagy induction is a tor- and tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis

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Fig. S1

tti^s450 larvae contain fewer replicating IECs than WT larvae. (A) Sagittal sections of the intestine of WT and tti^s450 zebrafish larvae at 72 hpf showing cells that accumulated BrdU (black arrows) during a 30 min exposure to this thymidine analogue at 72 hpf. BrdU-positive nuclei (brown) indicate cells in the S-phase of the cell cycle. Scale bars = 50 μm. (B) Quantitation of BrdU-positive IECs in three independent sagittal sections of WT and tti^s450 larvae at 72 hpf reveals that tti^s450 larvae contain approximately 50% fewer S-phase IECs than WT. *p<0.05. Data are represented as mean +/ SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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