FIGURE
Fig. S3
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- ZDB-FIG-130118-9
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- Freitas et al., 2012 - Hoxd13 contribution to the evolution of vertebrate appendages
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Fig. S3
Fin alterations are both hormone and hoxd13a dependent. A, Similar and1 expression domains were observed in wild type or hoxa4a-GR injected fins, either in the presence or the absence of the hormone (arrows). In fins injected with hoxd13a-GR, and1 is only downregulated in the presence of Dex (arrowhead). B, Expression of hoxa13b and cyclin d1 is not affected in hoxa4a-GR injected or wt fins in the presence of Dex (upper and middle panels, arrows). Distal expansion of hoxa13b and cyclin d1 domains is observed in hoxd13a-GR overexpressing fins (lower panel, arrowheads). |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Reprinted from Developmental Cell, 23(6), Freitas, R., Gómez-Marín, C., Wilson, J.M., Casares, F., and Gómez-Skarmeta, J.L., Hoxd13 contribution to the evolution of vertebrate appendages, 1219-1229, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell