FIGURE

Fig. 1

ID

ZDB-FIG-121212-24

Publication

Lane et al., 2012 - Otx but not mitf transcription factors are required for zebrafish retinal pigment epithelium development

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Fig. 1

Otx morpholino knockdown results in a variable degree of RPE deficits in zebrafish.

(A–B) Control morpholino (A) and otx1a/otx2 morpholino (B) injected embryos photographed at 35 hpf. RPE pigmentation is reduced in otx1a/otx2 morphants (black arrows) while neural crest derived melanocytes are unaffected (white arrows). (C–D) Ventral view of 5 dpf control morpholino (C) and otx1a/otx2 morpholino (D) injected larvae. The phenotype of otx1a/otx2 morphants can vary in severity between eyes of the same embryo, with one eye displaying a minor coloboma phenotype (black arrow) and the other eye displaying a major coloboma phenotype (white arrow).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-otx2a + MO1-otx2b
Knockdown Reagents:	MO1-otx2a MO1-otx2b
Observed In:	eye eye pigmentation
Stage Range:	Prim-15 to Day 5

Phenotype Detail

Acknowledgments

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