ZFIN Morpholino: MO1-otx2b

Target Location

Genome Build: GRCz11Chromosome: 17

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-otx2b

No data available

Phenotype

Phenotype resulting from MO1-otx2b

No data available

Phenotype of all Fish created by or utilizing MO1-otx2b

Phenotype	Fish	Conditions	Figures
optic fissure closure incomplete, abnormal	WT + MO1-otx1 + MO1-otx2b	standard conditions	Fig. 2 from Lane et al., 2012
eye perforate, abnormal	WT + MO1-otx1 + MO1-otx2b	standard conditions	Fig. 2 from Lane et al., 2012
eye pigmentation decreased occurrence, abnormal	WT + MO1-otx2a + MO1-otx2b	standard conditions	Fig. 1 from Lane et al., 2012
retinal pigmented epithelium ventral region absent, abnormal	WT + MO1-otx2a + MO1-otx2b	standard conditions	Fig. 3 from Lane et al., 2012
optic fissure closure incomplete, abnormal	WT + MO1-otx2a + MO1-otx2b	standard conditions	Fig. 2 from Lane et al., 2012

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Citations

Include unpublished citations

Staudt, N., Giger, F.A., Fielding, T., Hutt, J.A., Foucher, I., Snowden, V., Hellich, A., Kiecker, C., Houart, C. (2019) Pineal progenitors originate from a non-neural territory limited by FGF signalling. Development (Cambridge, England). 146(22):
Albuixech-Crespo, B., López-Blanch, L., Burguera, D., Maeso, I., Sánchez-Arrones, L., Moreno-Bravo, J.A., Somorjai, I., Pascual-Anaya, J., Puelles, E., Bovolenta, P., Garcia-Fernàndez, J., Puelles, L., Irimia, M., Ferran, J.L. (2017) Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain. PLoS Biology. 15:e2001573
Li, W.H., Zhou, L., Li, Z., Wang, Y., Shi, J.T., Yang, Y.J., Gui, J.F. (2015) Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation. International journal of biological sciences. 11(6):688-700
Su, C.Y., Kemp, H.A., and Moens, C.B. (2014) Cerebellar development in the absence of Gbx function in zebrafish. Developmental Biology. 386(1):181-90
Lane, B.M., and Lister, J.A. (2012) Otx but not mitf transcription factors are required for zebrafish retinal pigment epithelium development. PLoS One. 7(11):e49357
Tseng, W.F., Jang, T.H., Huang, C.B., and Yuh, C.H. (2011) An evolutionarily conserved kernel of gata5, gata6, otx2 and prdm1a operates in the formation of endoderm in zebrafish. Developmental Biology. 357(2):541-57
Scholpp, S., Foucher, I., Staudt, N., Peukert, D., Lumsden, A., and Houart, C. (2007) Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development (Cambridge, England). 134(17):3167-3176
Foucher, I., Mione, M., Simeone, A., Acampora, D., Bally-Cuif, L., and Houart, C. (2006) Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants. Development (Cambridge, England). 133(10):1891-1900

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