FIGURE

Fig. 1

ID

ZDB-FIG-120810-16

Publication

Goudarzi et al., 2012 - Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility

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Fig. 1

Lack of Bleb Formation in PGCs Knocked Down for Dnd Is Correlated with Reduced Contractility(A) Control germ cells form blebs in the direction of migration. Asterisks mark bleb initiation.(B) Lack of blebs in cells depleted for the Dnd protein.(C) Cortex ablation induces blebs in control cells.(D) Lack of bleb induction by a similar manipulation in cells knocked down for Dnd.(E) MLCK restores bleb formation in response to cortex ablation.Red arrowheads indicate the ablation point. See also Movies S1 and S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-dnd1
Knockdown Reagent:	MO1-dnd1
Observed In:	primordial germ cell primordial germ cell bleb primordial germ cell cell motility
Stage:	Shield

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 23(1), Goudarzi, M., Banisch, T.U., Mobin, M.B., Maghelli, N., Tarbashevich, K., Strate, I., van den Berg, J., Blaser, H., Bandemer, S., Paluch, E., Bakkers, J., Toli-Nørrelykke, I.M., and Raz, E., Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility, 210-218, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell