FIGURE

Fig. 3

ID

ZDB-FIG-120517-3

Publication

Gongal et al., 2011 - Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning

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Fig. 3

hmx4 morphants have defects in RA signaling. (A) otx2 is expanded in hmx4 morphants (extent of domain marked by the black line), while vhnf1 (B) and meis3 (C) are reduced in hmx4 morphants at 90% epiboly. (D) hoxd4a (blue) in 10s hmx4 morphants is reduced, while krox20 (red) expression in r3 and r5 is unchanged.

Expression Data

Genes:	hnf1ba hoxd4a meis3 otx2b
Fish:	AB AB + MO1-hmx4 + MO2-hmx4 + MO4-tp53
Knockdown Reagents:	MO1-hmx4 MO2-hmx4 MO4-tp53
Anatomical Terms:	neural plate neuroectoderm rhombomere 7 spinal cord neural rod
Stage Range:	90%-epiboly to 10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 355(1), Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., and Waskiewicz, A.J., Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning, 55-64, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.