ZFIN ID: ZDB-FIG-111028-9
Hale et al., 2011 - Netrin Signaling Breaks the Equivalence between Two Identified Zebrafish Motoneurons Revealing a New Role of Intermediate Targets. PLoS One   6(10):e25841 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Prim-25

Fig. 8 Netrins are unnecessary for CaP axons to extend to intermediate targets.

Projected confocal stacks of GFP-expressing motor axons in living Tg(mnx1:GFP) embryos injected with various MOs. A–C. In standard control MO-injected embryos CaP axons extend to the second intermediate target by 24 hpf (A), the third intermediate target by 30 hpf (B), and by 36 hpf have extended past the third intermediate target and wrap around the ventral aspect of the myotome (C). In ntn1a SBMO (D–F), ntn1b SBMO (G–I), and ntn2 SBMO (J–L) injected embryos the time course of CaP axon outgrowth was the same as in controls (A–C). Scale bar = 20 μm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
ml2Tg + MO1-ntn2 standard conditions Prim-25 axon extension process quality, normal
ml2Tg + MO2-ntn1a standard conditions Prim-25 axon extension process quality, normal
ml2Tg + MO3-ntn1b standard conditions Prim-25 axon extension process quality, normal
Acknowledgments:
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