FIGURE

Fig. S5

ID

ZDB-FIG-101122-72

Publication

North et al., 2010 - PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

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Fig. S5

The interaction between APAP, NAC, and EtOH is conserved in zebrafish embryos. (A) Transgenic lfabp:GFP liver reporter zebrafish embryos were exposed to APAP (10 mM), NAC (10 mM), and 0.5% EtOH as indicated. Fluorescence microscopy at 120 hpf revealed the beneficial effect of NAC and the detrimental outcome of combined APAP and EtOH exposures. NAC can rescue the effects of APAP. Short-term EtOH exposure increases liver size. EtOH exerts synergistic liver toxicity with APAP, which cannot be reversed by NAC. (B) Schematic representation of the fraction of zebrafish with decreased liver size, analyzed by in situ hybridization for lfabp.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA