FIGURE

Fig. 1

ID

ZDB-FIG-101122-63

Publication

North et al., 2010 - PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

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Fig. 1

Acetaminophen causes liver toxicity in adult zebrafish. Adult zebrafish were exposed to APAP for 24 h. (A) Total liver GSH was significantly diminished after exposure to 10 mM APAP. *t test, P d 0.001, n e 4. (B) ALT levels were measured 6 hpe to 5, 10, and 25 mM APAP. *Significant vs. control. **Significant vs. 5 mM, ANOVA, P < 0.01, n = 20/sample for three replicates. (Inset) ALT levels measured over time after exposure to 5 and 10 mM APAP rose over the first 24 hpe (n e 10/measurement). (C) Effects of increasing APAP doses on liver histology; hepatocyte necrosis, sinusoidal widening, and focal hemorrhage can be seen.

Expression Data

Expression Detail

Antibody Labeling

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Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA