FIGURE
Fig. 4
- ID
- ZDB-FIG-101122-65
- Publication
- North et al., 2010 - PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury
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Fig. 4
Prostaglandin E2 (PGE2) inhibits APAP toxicity by enhancing proliferation and inhibiting apoptosis. (A) PGE2 (10 μM) increases embryonic liver growth (at 120 hpf) and diminishes 10 mM APAP toxicity in lfabp:GFP embryos. (B) Embryonic lfabp expression at 96 hpf, by qPCR, after the indicated treatment (ANOVA, n = 5). *P = 0.06. **P < 0.001. ***P = 0.025. (C) Survival in adult zebrafish (n = 10/treatment) after APAP is improved by dmPGE2. (D) lfabp expression in the adult liver, by qPCR, is reduced by APAP and rescued by dmPGE2 (ANOVA, n = 4). *P = 0.002. **P = 0.0057. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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