ZFIN ID: ZDB-FIG-101122-57
Ragvin et al., 2010 - Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proceedings of the National Academy of Sciences of the United States of America   107(2):775-780 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Prim-15

Fig. S4 (A) irx3a and nkx2.2a knockdown severely perturb hlxb9 expression in pancreatic endocrine cells. Representative confocal projections of 30 hpf hlxb9: GFP larvae injected with control morpholino (A–C), irx3a morpholino (D and E), and irx3a/nkx2.2a morpholinos (F, G, and H). (B) irx3a and nkx2.2a knockdown increases hb9 expression in spinal cord motor neurons (MNs). Representative confocal projections of 30 hpf hb9:GFP larvae injected with control morpholino (A), irx3a morpholino (B), and irx3a/nkx2.2a morpholinos (C).

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP ml2Tg control Prim-15 posterior pancreatic bud IFL
Prim-15 spinal cord motor neuron IFL
ml2Tg + MO2-irx3a standard conditions Prim-15 posterior pancreatic bud IFL
Prim-15 spinal cord motor neuron IFL
ml2Tg + MO2-irx3a + MO3-nkx2.2a standard conditions Prim-15 posterior pancreatic bud IFL
Prim-15 spinal cord motor neuron IFL
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA