FIGURE

Fig. 6

ID

ZDB-FIG-101104-7

Publication

Raphael et al., 2010 - Schwann cells reposition a peripheral nerve to isolate it from postembryonic remodeling of its targets

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Fig. 6

Nerves become disorganized during development in mutants lacking Schwann cells. (A-O) Antibody staining for acetylated tubulin shows the position of the PLLn. (A-E) Wild-type nerves remain anchored at the horizontal myoseptum and run straight along the length of the embryo at all times examined (48 hpf, 3-6 dpf), but the neuromasts migrate ventrally over time (arrowheads). Some axons branch from the main bundle to innervate individual neuromasts. (F-O) Nerves in erbb2^st61 (F-J) and sox10/cls^t3 (K-O) mutants appear normal at 48 hpf but become progressively disorganized (3-6 dpf) and often track with migrating neuromasts (arrowheads). Excess neuromasts are present in nerves lacking Schwann cells (F-O). Asterisks indicate the presence of pigment cells. Scale bar: 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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