ZFIN ID: ZDB-FIG-100422-62
Schonthaler et al., 2010 - The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness. Mechanisms of Development   127(3-4):203-219 Full text @ Mech. Dev.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Days 30-44 to Adult

Fig. 8 Skeletal analyses by whole-mount staining reveal craniofacial defects and a normal ocular skeleton. Alizarin red staining, except for G, which is stained with Alcian blue. (A–C) bum-/-, (D–F) wild-type (wt). Comparative linear dimensions are shown and indicated by a–g. (A) dorsal view, bum-/- 30 mm SL; (B) lateral view, bum-/- 30 mm SL; (C) dorsal view after removal of jaws, eyes and opercular complex, bum-/- 21 mm SL; (D) dorsal view, wt 30 mm SL; (E) lateral view, wt 30 mm SL; (F) dorsal view after removal of jaws, eyes and opercular complex, wt 21 mm SL; (G) bum-/- 10 mm SL, Alcian blue-stained; (H) scleral ossicles, bum-/- 30 mm SL; (I) scleral ossicles of wt 21 mm SL, top, and bum-/- 21 mm SL, below; (J) supraorbital bone of wt 21 mm SL, top, and bum-/- 21 mm SL, below; (K) suborbital bone of wt 21 mm SL, top, and bum-/- 21 mm SL, below; (L) lateral bones including pterygoid complex, preopercle, symplectic, and quadrate bones, wt 21 mm SL, top, and bum-/- 21 mm SL, below; (M) hyomandibular, wt 21 mm SL, right, and bum-/- 21 mm SL, left; (N) subopercle, wt 21 mm SL, right, and bum-/- 21 mm SL, left; (O) interopercle, wt 21 mm SL, top, and bum-/- 21 mm SL, below; (P) mandible, wt 30 mm SL; (Q) mandible, bum-/- 30 mm SL; (R) mandible, bum-/- 28 mm SL; (S) mandible, bum-/- 30 mm SL; (T) maxilla complex, bum-/- 30 mm SL. Abbreviations: cb, ceratobranchials; ch, ceratohyal cartilage; en, entopterygoid; mc, Meckel’s cartilage; mx, maxilla; p, palatine; pm, premaxilla; q, quadrate; sc, scleral cartilage; so, scleral ossicles; sy, symplectic. Scale bars: 500 μm unless otherwise indicated.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
bumtg413/tg413 standard conditions Days 30-44 sclerotic cartilage morphology, normal
Adult cranium decreased size, abnormal
Adult cranium structure, abnormal
Adult entopterygoid decreased size, abnormal
Adult hyomandibula decreased size, abnormal
Adult ossification disrupted, abnormal
Adult ventral mandibular arch malformed, abnormal
Acknowledgments:
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Reprinted from Mechanisms of Development, 127(3-4), Schonthaler, H.B., Franz-Odendaal, T.A., Hodel, C., Gehring, I., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R., The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness, 203-219, Copyright (2010) with permission from Elsevier. Full text @ Mech. Dev.