ZFIN ID: ZDB-FIG-100422-61
Schonthaler et al., 2010 - The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness. Mechanisms of Development   127(3-4):203-219 Full text @ Mech. Dev.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Day 5 to Adult

Fig. 7 bum-/- zebrafish are severely visually impaired. (A–B) Lateral (A) and dorsal (B) views of adult bum-/- mutant zebrafish and sibling (wild-type) zebrafish swimming together. Note the significantly darker overall appearance of the mutant fish (asterisks; lower individual in A and upper individual in B, respectively) compared to their siblings when kept under bright light conditions. (C–F) Optokinetic response of bum-/- mutants and siblings at 5 dpf (C, D) and 7 dpf (E, F). Both contrast sensitivity (C, E) and visual acuity (D, F) are affected by the mutation. In both paradigms the eye velocity as a measure of visual performance is lower in bum-/- mutant larvae compared to their siblings. The inset in C shows a schematic representation of the experimental set-up.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
bumtg413/tg413 standard conditions Day 5 optokinetic behavior disrupted, abnormal
Days 7-13 optokinetic behavior disrupted, abnormal
Adult detection of light stimulus disrupted, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Mechanisms of Development, 127(3-4), Schonthaler, H.B., Franz-Odendaal, T.A., Hodel, C., Gehring, I., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R., The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness, 203-219, Copyright (2010) with permission from Elsevier. Full text @ Mech. Dev.