FIGURE

Fig. 3

ID
ZDB-FIG-090224-48
Publication
Dowling et al., 2009 - Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy
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Fig. 3

Abnormal histopathology in 72 hpf myotubularin morphants.

(A) H/E stained longitudinal myofibers from myotubular myopathy (MTM) and age matched control (CTL) human muscle biopsies. Arrows point to abnormal nuclei. (B) H/E stained longitudinal myofibers from control (CTL MO) and myotubularin (MTM MO) morphant 72 hpf embryos. Myonuclei are abnormally rounded (arrows), and there is increased space between fibers (*). (C) Toluidine blue stained semi-thin sections from 72 hpf morphants. Myonuclei from myotubularin morphants are large, abnormally rounded, and contain discrete nucleoli (arrows). Sarcomeric units, however, are normal in appearance. Scale bar = 20 mm.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage: Protruding-mouth

Phenotype Detail
Acknowledgments
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