FIGURE

Fig. S4

ID
ZDB-FIG-080516-26
Publication
Shin et al., 2008 - Multiple roles for Med12 in vertebrate endoderm development
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Fig. S4

Med12 regulates anterior sox17 expression in endodermal cells during gastrulation. Wild-type and med12s432 mutants were analyzed at 60% (A–B′) and 90% (C–E′) epiboly for bon (A, A′), gata5 (B, B′), sox17 (C, C′), foxa2 (D, D′), and cas (E, E′) expression. White dashed lines in C and C′ surround a subset of sox17-positive cells in the anterior region. Note that, in med12s432 mutants, many of these cells are missing, whereas other early endodermal markers show comparable expression in wild-type and mutants. After in situ hybridization, the embryos were genotyped to unambiguously identify the mutants. A–B′ are animal pole views; C–E′ are dorsal views, anterior to the top.

Expression Data
Genes:
Fish:
Anatomical Terms:
Stage Range: Shield to 90%-epiboly

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: 90%-epiboly

Phenotype Detail
Acknowledgments
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Reprinted from Developmental Biology, 317(2), Shin, C.H., Chung, W.S., Hong, S.K., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., and Stainier, D.Y., Multiple roles for Med12 in vertebrate endoderm development, 467-479, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.