Fig. 7
- ID
- ZDB-FIG-080416-13
- Publication
- Huang et al., 2008 - Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants
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Blocking of histamine synthesis causes blood vessel branching defects in wild-type zebrafish embryos. (A) In a 32 hpf wild-type embryo, the developing caudal vein formed a transient vascular plexus. (B) When treated with 900 μM of the histamine synthesis blocker, urocanic acid, the caudal vein of a wild-type sibling formed much fewer vascular branches and even developed a reg6-like swollen lumen. Red arrows, caudal veins. (C) Quantitative results of the suppression of urocanic acid on blood vessel branching in wild-type zebrafish embryos. Two clutches of wild-type embryos (blue and red bars) were treated with the vehicle (0.0015 hydrochloric acid), or 300 or 900 μM of urocanic acid in egg water, from 26–36 hpf at 28.5°C. The percentage of embryos with less branched caudal vein was scored at the end of treatment (Y-axis, n = 40 unless otherwise specified). |
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Stage Range: | Prim-15 to Adult |
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Stage: | Prim-15 |