FIGURE

Fig. 4

ID

ZDB-FIG-080416-10

Publication

Huang et al., 2008 - Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants

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Fig. 4

Suppression of the reg6 embryonic phenotype by SKF91488 and histamine. (A, bright field; B, GFP) Untreated reg6 embryos developed dilated caudal veins at 33°C (yellow arrows). (C, bright field; D, GFP) reg6 embryos treated with 10 μM HMT inhibitor SKF91488 developed normal caudal veins. Anterior, left; dorsal, top. (E) Typically, almost 70% of reg6 embryos formed dilated caudal veins at 33°C (blue bar). The penetrance was reduced by SKF91488 (red bars, n = 50) and histamine (green bars, n = 50).

Expression Data

Gene:	EGFP
Fish:	reg6^j21/j21; y1Tg
Condition:	chemical treatment: EC 2.1.1.8 (histamine N-methyltransferase) inhibitor
Anatomical Term:	caudal vein plexus
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	reg6^j21/j21; y1Tg
Condition:	chemical treatment: EC 2.1.1.8 (histamine N-methyltransferase) inhibitor
Observed In:	caudal vein plexus
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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