FIGURE

Fig. 4

ID

ZDB-FIG-070502-31

Publication

Hagos et al., 2007 - Time-dependent patterning of the mesoderm and endoderm by Nodal signals in zebrafish

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Fig. 4

Nodal signals pattern the mesoderm during a three-hour time window. (A1-A8) Trunk somites form in embryos treated at 3.7 h (A1, 5), but flh is expressed in four ectodermal domains (A6). (B1-B8) Embryos treated at 4 h contain more somites (B5). flh is expressed at the midline and small amounts of notochord tissue are observed in live embryos (B1, arrow). pax2.1 expression is also observed (B7). At later time points, embryos have progressively more somites and more notochord (C1-E7). flh expression extends further up the midline and pax2.1 is expressed more strongly. Kupffer's vesicle forms in embryos treated 4.3 h (C3, arrowhead). shhb is not expressed in embryos treated before gastrulation (A8-E8). Images of live embryos at 24 h, anterior to the left (A1-E1; A2-E2) or 14hpf (A3-E3); dorsal views of fixed embryos at 10 h (A4-E4; A6-E6; A8-D8) or 14 h (A5-E5; A7-E7). Control embryos are depicted in Fig. 1J-S, which are from the same experiment.

Expression Data

Genes:	myod1 noto pax2a shhb tbxta
Fish:	WIK
Condition:	chemical treatment: pharmaceutical
Anatomical Terms:	axial mesoderm ectoderm intermediate mesoderm notochord somite
Stage Range:	Bud to 10-13 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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