| 
            Phenotype
         | 
            
                Fish
             | 
            
                Conditions
             | 
        
            Figures
         | 
    
    
    
        
            | 
                interhyal-hyosymplectic joint cartilage development increased process quality, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  , 
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                hyosymplectic cartilage fused with interhyal cartilage, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 skeleton joint acana expression increased amount, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint chondrocyte increased size, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint cartilage development increased process quality, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  , 
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint chondrocyte increased size, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint malformed, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal cartilage fused with interhyal cartilage, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 skeleton joint col2a1a expression increased amount, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 skeleton embryonic skeletal joint development decreased process quality, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  , 
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint malformed, abnormal
             | 
                
                    irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                Meckel's cartilage absent, abnormal
             | 
                
                    irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                palatoquadrate arch fused with hyomandibula, abnormal
             | 
                
                    irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                ceratobranchial cartilage absent, abnormal
             | 
                
                    irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                palatoquadrate cartilage absent, abnormal
             | 
                
                    irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                ceratohyal cartilage decreased size, abnormal
             | 
                
                    irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                Meckel's cartilage fused with ceratohyal bone, abnormal
             | 
                
                    irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                quadrate fused with anguloarticular, abnormal
             | 
                
                    irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                ceratohyal bone fused with ceratobranchial 1 bone, abnormal
             | 
                
                    irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint chondrocyte EGFP expression increased amount, abnormal
             | 
                
                    irx7el538/el538; el10Tg; el483Tg
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint chondrocyte EGFP expression increased amount, abnormal
             | 
                
                    irx7el538/el538; el10Tg; el483Tg
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint chondrocyte EGFP expression increased amount, abnormal
             | 
                
                    irx7el538/el538; el10Tg; nu13Tg
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint chondrocyte EGFP expression increased amount, abnormal
             | 
                
                    irx7el538/el538; el10Tg; nu13Tg
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint cartilage development increased process quality, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint chondrocyte development increased process quality, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint absent, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Askary et al., 2017 
                
             | 
        
    
        
            | 
                hyosymplectic cartilage fused with interhyal cartilage, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Askary et al., 2017 
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 skeleton joint ab1-col2a labeling increased amount, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 skeleton lacks all parts of type interhyal-hyosymplectic joint, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal cartilage fused with interhyal cartilage, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Askary et al., 2017 
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint chondrocyte increased size, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint absent, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Askary et al., 2017 
                
             | 
        
    
        
            | 
                symplectic decreased length, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Askary et al., 2017 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint malformed, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint chondrocyte development increased process quality, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint chondrocyte increased size, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 skeleton embryonic skeletal joint development decreased process quality, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  , 
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint cartilage development increased process quality, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                ceratohyal-interhyal joint malformed, abnormal
             | 
                
                    irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 2  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 skeleton embryonic skeletal joint development decreased process quality, abnormal
             | 
                
                    irx7el538/el538; trps1j1271aGt; el10Tg
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 skeleton joint EGFP expression decreased amount, abnormal
             | 
                
                    irx7el538/el538; trps1j1271aGt; el10Tg
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Askary et al., 2015 
                
             | 
        
    
        
            | 
                opercle decreased size, abnormal
             | 
                
                    emx2el586/el586; irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Askary et al., 2017 
                
             | 
        
    
        
            | 
                symplectic decreased length, abnormal
             | 
                
                    emx2el586/el586; irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Askary et al., 2017 
                
             | 
        
    
        
            | 
                interhyal-hyosymplectic joint malformed, abnormal
             | 
                
                    emx2el586/el586; irx5ael574/el574; irx7el538/el538
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 6  
                    
                    from Askary et al., 2017 
                
             | 
        
    
        
            | 
                cranial neural crest cell sox10 expression decreased amount, abnormal
             | 
                
                    irx1bel833/el833; irx7el540/el540; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                pharyngeal arch 3-7 cranial neural crest cell decreased amount, abnormal
             | 
                
                    irx1bel833/el833; irx7el540/el540; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                neural crest cell dlx2a expression decreased amount, abnormal
             | 
                
                    irx1bel833/el833; irx7el540/el540; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 4  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                pharyngeal arch 2 cranial neural crest cell decreased amount, abnormal
             | 
                
                    irx1bel833/el833; irx7el540/el540; irx4bel834/el834; el10Tg
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                pharyngeal arch 1 cranial neural crest cell absent, abnormal
             | 
                
                    irx1bel833/el833; irx7el540/el540; irx4bel834/el834; el10Tg
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                palatoquadrate cartilage absent, abnormal
             | 
                
                    irx1bel833/el833; irx7el540/el540; irx1ael830/+; irx2ael831/+; irx4ael832/+; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                Meckel's cartilage absent, abnormal
             | 
                
                    irx1bel833/el833; irx7el540/el540; irx1ael830/+; irx2ael831/+; irx4ael832/+; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                Meckel's cartilage fused with ceratohyal bone, abnormal
             | 
                
                    irx3ael835/el835; irx3bel837/el837; irx5ael576/el576; irx5bel722/el722; irx6ael836/el836; irx7el540/el540
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 7  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                palatoquadrate cartilage absent, abnormal
             | 
                
                    irx1bel833/el833; irx3ael835/el835; irx3bel837/el837; irx5ael576/el576; irx5bel722/el722; irx6ael836/el836; irx7el540/el540; irx1ael830/+; irx2ael831/+; irx4ael832/+; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                ceratohyal cartilage decreased size, abnormal
             | 
                
                    irx1bel833/el833; irx3ael835/el835; irx3bel837/el837; irx5ael576/el576; irx5bel722/el722; irx6ael836/el836; irx7el540/el540; irx1ael830/+; irx2ael831/+; irx4ael832/+; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                Meckel's cartilage absent, abnormal
             | 
                
                    irx1bel833/el833; irx3ael835/el835; irx3bel837/el837; irx5ael576/el576; irx5bel722/el722; irx6ael836/el836; irx7el540/el540; irx1ael830/+; irx2ael831/+; irx4ael832/+; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                neurocranium absent, abnormal
             | 
                
                    irx1bel833/el833; irx3ael835/el835; irx3bel837/el837; irx5ael576/el576; irx5bel722/el722; irx6ael836/el836; irx7el540/el540; irx1ael830/+; irx2ael831/+; irx4ael832/+; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             | 
        
    
        
            | 
                ceratobranchial cartilage absent, abnormal
             | 
                
                    irx1bel833/el833; irx3ael835/el835; irx3bel837/el837; irx5ael576/el576; irx5bel722/el722; irx6ael836/el836; irx7el540/el540; irx1ael830/+; irx2ael831/+; irx4ael832/+; irx4bel834/el834
                 | 
                
                    standard conditions
                 | 
            
                
                    
                        Fig. 3  
                    
                    from Farmer et al., 2021 
                
             |