PUBLICATION

Vertebrate genome evolution and the zebrafish gene map

Authors
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S.
ID
ZDB-PUB-980317-2
Date
1998
Source
Nature Genetics   18: 345-349 (Journal)
Registered Authors
Abduljabbar, Tariq, Amores, Angel, Beier, David R., Brownlie, Alison J., Donovan, Adriana, Egan, Elizabeth S., Force, Allan G., Fritz, Andreas, Gates, Michael A., Gong, Zhiyuan, Goutel, Carole, Horne-Badovinac, Sally, Johnson, Stephen L., Joly, Jean-Stephane, Kelsh, Robert, Knapik, Ela W., Larhammar, Dan, Liao, Eric, Paw, Barry, Postlethwait, John H., Ransom, David G., Rosa, Frederic, Singer, Amy, Talbot, William S., Westerfield, Monte, Yan, Yi-Lin, Yelick, Pamela C., Zon, Leonard I.
Keywords
none
MeSH Terms
  • Animals
  • Chromosome Mapping
  • Evolution, Molecular
  • Genes/genetics
  • Genome
  • Multigene Family
  • Polyploidy
  • Vertebrates/genetics*
  • Vertebrates/physiology*
  • Zebrafish/genetics*
PubMed
9537416 Full text @ Nat. Genet.
Abstract
In chordate phylogeny, changes in the nervous system, jaws, and appendages transformed meek filter feeders into fearsome predators. Gene duplication is thought to promote such innovation. Vertebrate ancestors probably had single copies of genes now found in multiple copies in vertebrates and gene maps suggest that this occurred by polyploidization. It has been suggested that one genome duplication event occurred before, and one after the divergence of ray-finned and lobe-finned fishes. Holland et al., however, have argued that because various vertebrates have several HOX clusters, two rounds of duplication occurred before the origin of jawed fishes. Such gene-number data, however, do not distinguish between tandem duplications and polyploidization events, nor whether independent duplications occurred in different lineages. To investigate these matters, we mapped 144 zebrafish genes and compared the resulting map with mammalian maps. Comparison revealed large conserved chromosome segments. Because duplicated chromosome segments in zebrafish often correspond with specific chromosome segments in mammals, it is likely that two polyploidization events occurred prior to the divergence of fish and mammal lineages. This zebrafish gene map will facilitate molecular identification of mutated zebrafish genes, which can suggest functions for human genes known only by sequence.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes