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ZFIN ID: ZDB-PERS-960805-642
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BIOGRAPHY AND RESEARCH INTERESTS
Gene duplication is a common event, and principles that govern the evolution of duplicated genes impact the molecular genetic mechanisms of morphogenesis. An understanding of how duplicated genes evolve is especially important among fish because whole genome duplication has been a recurring theme in ray-fin fish phylogeny. To investigate genome structure in a teleost fish, we have placed over 1524 genes and ESTs and over 610 SSLPs (simple sequence length polymorphisms) on a zebrafish doubled haploid meiotic mapping panel (the Heat Shock Panel). Our mapping has revealed the following general principles: (1) The zebrafish genome shares large regions of conserved synteny with mammalian genomes, sometimes about as long as individual mammalian chromosomes. For example, results suggest that most of the loci on human chromosome 17 have remained syntenic since the divergence of ray-fin and lobe fin fish 450 million years ago. (2) Within conserved regions, intrachromosomal rearrangements have frequently altered gene order; thus, inversions have been much more common than chromosomal translocations. (3) Zebrafish chromosomes are mosaics of mammalian chromosomes. (4) Zebrafish frequently has two orthologues of many mammalian genes (about 30%), and these map in duplicated chromosome segments. This result suggests an ancient whole genome duplication event in the zebrafish lineage. When did this genome duplication occur in ray-fin fish phylogeny? Data remain scanty, but are consistent with the hypothesis that an ancient tetraploidization event occurred before the teleost radiation, and so is in the genomic heritage of all teleosts.
After gene duplication, usually one gene copy becomes mutationally silenced and disappear over time (nonfunctionalization). Alternatively, both duplicate copies may be preserved if either(1) beneficial mutations occur in one or both copies that allow the evolution of new functions (neofunctionalization), or if (2) degenerative mutations result in the partitioning of the tasks of the ancestral gene subfunctionalization). Thus, gene duplicates in teleost fish may sum together to perform the functions of their single copy mammalian orthologue. Furthermore, if duplicate gene subfunctions remained unresolved at the time that different teleost lineages diverged, then truly orthologous genes in different fish species may have different functions in development. And if both duplicate genes were completely intact at the time of lineage divergence, then independent nonfunctionalization of different copies in different lineages could lead to different gene contents in orthologous chromosome segments of different teleosts. If the hypothesis of a shared genome duplication is substantiated for teleost fish, then the comparative biology of the molecular genetic mechanisms of morphogenesis must address these principles that appear to govern the evolution of duplicate genes.
PUBLICATIONS
Baer, L., Barthelson, K., Postlethwait, J.H., Adelson, D.L., Pederson, S.M., Lardelli, M. (2024) Differential allelic representation (DAR) identifies candidate eQTLs and improves transcriptome analysis. PLoS Computational Biology. 20:e1011868e1011868
Cumplido, N., Arratia, G., Desvignes, T., Muñoz-Sánchez, S., Postlethwait, J.H., Allende, M.L. (2024) Hox genes control homocercal caudal fin development and evolution. Science advances. 10:eadj5991eadj5991
Parey, E., Louis, A., Montfort, J., Bouchez, O., Roques, C., Iampietro, C., Lluch, J., Castinel, A., Donnadieu, C., Desvignes, T., Floi Bucao, C., Jouanno, E., Wen, M., Mejri, S., Dirks, R., Jansen, H., Henkel, C., Chen, W.J., Zahm, M., Cabau, C., Klopp, C., Thompson, A., Robinson-Rechavi, M., Braasch, I., Lecointre, G., Bobe, J., Postlethwait, J.H., Berthelot, C., Crollius, H.R., Guiguen, Y. (2023) Genome structures resolve the early diversification of teleost fishes. Science (New York, N.Y.). 379:572575572-575
Petersen, A.M., Small, C.M., Yan, Y.L., Wilson, C., Batzel, P., Bremiller, R.A., Buck, C.L., von Hippel, F.A., Cresko, W.A., Postlethwait, J.H. (2022) Evolution and developmental expression of the sodium-iodide symporter (NIS, slc5a5) gene family: Implications for perchlorate toxicology. Evolutionary Applications. 15:1079-1098
Valdivieso, A., Wilson, C.A., Amores, A., da Silva Rodrigues, M., Nóbrega, R.H., Ribas, L., Postlethwait, J.H., Piferrer, F. (2022) Environmentally-induced sex reversal in fish with chromosomal vs. polygenic sex determination. Environmental research. 213:113549
Annona, G., Ferran, J.L., De Luca, P., Conte, I., Postlethwait, J.H., D'Aniello, S. (2022) Expression Pattern of nos1 in the Developing Nervous System of Ray-Finned Fish. Genes. 13(5)
Brunsdon, H., Brombin, A., Peterson, S., Postlethwait, J.H., Patton, E.E. (2022) Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Development (Cambridge, England). 149(10):
Desvignes, T., Robbins, A.E., Carey, A.Z., Bailon-Zambrano, R., Nichols, J.T., Postlethwait, J.H., Stankunas, K. (2022) Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1306-1321
Desvignes, T., Bardou, P., Montfort, J., Sydes, J., Guyomar, C., George, S., Postlethwait, J.H., Bobe, J. (2022) FishmiRNA: An evolutionarily supported microRNA annotation and expression database for ray-finned fishes. Molecular Biology and Evolution. 39(2)
Yan, Y.L., Titus, T., Desvignes, T., BreMiller, R., Batzel, P., Sydes, J., Farnsworth, D., Dillon, D., Wegner, J., Phillips, J.B., Peirce, J., Dowd, J., Undiagnosed Diseases Network, Buck, C.L., Miller, A., Westerfield, M., Postlethwait, J.H. (2021) Erratum to: A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs. Genetics. 218(1)
Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
Yan, Y.L., Titus, T., Desvignes, T., BreMiller, R., Batzel, P., Sydes, J., Farnsworth, D., Dillon, D., Wegner, J., Phillips, J.B., Peirce, J., Dowd, J., Undiagnosed Diseases Network, Buck, C.L., Miller, A., Westerfield, M., Postlethwait, J.H. (2021) A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs. Genetics. 217(2)
Kimmel, C.B., Wind, A.L., Oliva, W., Ahlquist, S.D., Walker, C., Dowd, J., Blanco-Sánchez, B., Titus, T.A., Batzel, P., Talbot, J.C., Postlethwait, J.H., Nichols, J.T. (2020) Transgene-mediated skeletal phenotypic variation in zebrafish. Journal of Fish Biology. 98(4):956-970
Ganz, J., Melancon, E., Wilson, C., Amores, A., Batzel, P., Strader, M., Braasch, I., Diba, P., Kuhlman, J.A., Postlethwait, J.H., Eisen, J.S. (2019) Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development. Developmental Biology. 455:473-484
Yan, Y.L., Batzel, P., Titus, T., Sydes, J., Desvignes, T., Bremiller, R., Draper, B., Postlethwait, J.H. (2019) A Hormone That Lost Its Receptor: Anti-Müllerian Hormone (AMH) in Zebrafish Gonad Development and Sex Determination. Genetics. 213(2):529-553
Burrage, L.C., Reynolds, J.J., Baratang, N.V., Phillips, J.B., Wegner, J., McFarquhar, A., Higgs, M.R., Christiansen, A.E., Lanza, D.G., Seavitt, J.R., Jain, M., Li, X., Parry, D.A., Raman, V., Chitayat, D., Chinn, I.K., Bertuch, A.A., Karaviti, L., Schlesinger, A.E., Earl, D., Bamshad, M., Savarirayan, R., Doddapaneni, H., Muzny, D., Jhangiani, S.N., Eng, C.M., Gibbs, R.A., Bi, W., Emrick, L., Rosenfeld, J.A., Postlethwait, J., Westerfield, M., Dickinson, M.E., Beaudet, A.L., Ranza, E., Huber, C., Cormier-Daire, V., Shen, W., Mao, R., Heaney, J.D., Orange, J.S., University of Washington Center for Mendelian Genomics, Undiagnosed Diseases Network, Bertola, D., Yamamoto, G.L., Baratela, W.A.R., Butler, M.G., Ali, A., Adeli, M., Cohn, D.H., Krakow, D., Jackson, A.P., Lees, M., Offiah, A.C., Carlston, C.M., Carey, J.C., Stewart, G.S., Bacino, C.A., Campeau, P.M., Lee, B. (2019) Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. American journal of human genetics. 104(3):422-438
Kossack, M.E., High, S.K., Hopton, R.E., Yan, Y.L., Postlethwait, J.H., Draper, B.W. (2018) Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. Genetics. 211(1):219-233
Cal, L., MegÍas, M., Cerdá-Reverter, J.M., Postlethwait, J.H., Braasch, I., Rotllant, J. (2017) BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(7):697-708
Pasquier, J., Braasch, I., Batzel, P., Cabau, C., Montfort, J., Nguyen, T., Jouanno, E., Berthelot, C., Klopp, C., Journot, L., Postlethwait, J.H., Guiguen, Y., Bobe, J. (2017) Evolution of gene expression after whole-genome duplication: New insights from the spotted gar genome. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(7):709-721
Yan, Y.L., Desvignes, T., BreMiller, R., Wilson, C., Dillon, D., High, S., Draper, B., Buck, C.L., Postlethwait, J. (2017) The gonadal soma controls ovarian follicle proliferation through Gsdf in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(11):925-945
Wangler, M.F., Yamamoto, S., Chao, H.T., Posey, J.E., Westerfield, M., Postlethwait, J., Hieter, P., Boycott, K.M., Campeau, P.M., Bellen, H.J. (2017) Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research. Genetics. 207:9-27
Kroeger, P.T., Drummond, B.E., Miceli, R., McKernan, M., Gerlach, G.F., Marra, A.N., Fox, A., McCampbell, K.K., Leshchiner, I., Rodriguez-Mari, A., BreMiller, R., Thummel, R., Davidson, A.J., Postlethwait, J., Goessling, W., Wingert, R.A. (2017) The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Developmental Biology. 428(1):148-163
Granneman, J.G., Kimler, V.A., Zhang, H., Ye, X., Luo, X., Postlethwait, J.H., Thummel, R. (2017) Lipid droplet biology and evolution illuminated by the characterization of a novel Perilipin in teleost fish. eLIFE. 6
Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583
Postlethwait, J.H., Yan, Y.L., Desvignes, T., Allard, C., Titus, T., Le François, N.R., Detrich, H.W. (2016) Embryogenesis and early skeletogenesis in the Antarctic Bullhead notothen, Notothenia coriiceps. Developmental Dynamics : an official publication of the American Association of Anatomists. 245(11):1066-1080
Sukeena, J.M., Galicia, C.A., Wilson, J.D., McGinn, T., Boughman, J.W., Robison, B.D., Postlethwait, J.H., Braasch, I., Stenkamp, D.L., Fuerst, P.G. (2016) Characterization and Evolution of the Spotted Gar Retina. Journal of experimental zoology. Part B, Molecular and developmental evolution. 326(7):403-421
Talbot, J.C., Nichols, J.T., Yan, Y.L., Leonard, I.F., BreMiller, R.A., Amacher, S.L., Postlethwait, J.H., Kimmel, C.B. (2016) Pharyngeal morphogenesis requires fras1-itga8- dependent epithelial-mesenchymal interaction. Developmental Biology. 416(1):136-48
Askary, A., Smeeton, J., Paul, S., Schindler, S., Braasch, I., Ellis, N.A., Postlethwait, J., Miller, C.T., Crump, J.G. (2016) Ancient origin of lubricated joints in bony vertebrates. eLIFE. 5
Ding, H.L., Hooper, J.E., Batzel, P., Eames, B.F., Postlethwait, J.H., Artinger, K.B., Clouthier, D.E. (2016) MicroRNA Profiling during Craniofacial Development: Potential Roles for Mir23b and Mir133b. Frontiers in Physiology. 7:281
Petersen, A.M., Earp, N.C., Redmond, M.E., Postlethwait, J.H., von Hippel, F.A., Buck, C.L., Cresko, W.A. (2016) Perchlorate Exposure Reduces Primordial Germ Cell Number in Female Threespine Stickleback. PLoS One. 11:e0157792
Pasquier, J., Cabau, C., Nguyen, T., Jouanno, E., Severac, D., Braasch, I., Journot, L., Pontarotti, P., Klopp, C., Postlethwait, J.H., Guiguen, Y., Bobe, J. (2016) Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. BMC Genomics. 17:368
Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
Lin, J.C., Hu, S., Ho, P.H., Hsu, H.J., Postlethwait, J., Chung, B.C. (2016) Corrigendum. Two zebrafish hsd3b genes are distinct in function, expression and evolution. Endocrinology. 157:978
Tallafuss, A., Kelly, M., Gay, L., Gibson, D., Batzel, P., Karfilis, K.V., Eisen, J., Stankunas, K., Postlethwait, J.H., Washbourne, P. (2015) Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. BMC Genomics. 16:1100
Desvignes, T., Batzel, P., Berezikov, E., Eilbeck, K., Eppig, J.T., McAndrews, M.S., Singer, A., Postlethwait, J.H. (2015) miRNA Nomenclature: A View Incorporating Genetic Origins, Biosynthetic Pathways, and Sequence Variants. Trends in genetics : TIG. 31:613-26
Lin, J.C., Hu, S., Ho, P.H., Hsu, H.J., Postlethwait, J., Chung, B.C. (2015) Two zebrafish hsd3b genes are distinct in function, expression and evolution. Endocrinology. 156(8):2854-62
Braasch, I., Peterson, S.M., Desvignes, T., McCluskey, B.M., Batzel, P., Postlethwait, J.H. (2015) A new model army: Emerging fish models to study the genomics of vertebrate Evo-Devo. Journal of experimental zoology. Part B, Molecular and developmental evolution. 324(4):316-41
Huang, J., Zhong, Z., Wang, M., Chen, X., Tan, Y., Zhang, S., He, W., He, X., Huang, G., Lu, H., Wu, P., Che, Y., Yan, Y.L., Postlethwait, J.H., Chen, W., Wang, H. (2015) Circadian modulation of dopamine levels and dopaminergic neuron development contributes to attention deficiency and hyperactive behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:2572-87
Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P., Zhong, Z., Hong, F., Wang, G., Postlethwait, J.H., Wang, H. (2015) Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Scientific Reports. 5:8113
Gehrke, A.R., Schneider, I., de la Calle-Mustienes, E., Tena, J.J., Gomez-Marin, C., Chandran, M., Nakamura, T., Braasch, I., Postlethwait, J.H., Gómez-Skarmeta, J.L., Shubin, N.H. (2015) Deep conservation of wrist and digit enhancers in fish. Proceedings of the National Academy of Sciences of the United States of America. 112(3):803-8
Wilson, C.A., High, S.K., McCluskey, B.M., Amores, A., Yan, Y.L., Titus, T.A., Anderson, J.L., Batzel, P., Carvan, M.J., Schartl, M., Postlethwait, J.H. (2014) Wild Sex in Zebrafish: Loss of the Natural Sex Determinant in Domesticated Strains. Genetics. 198(3):1291-308
Braasch, I., Guiguen, Y., Loker, R., Letaw, J.H., Ferrara, A., Bobe, J., and Postlethwait, J.H. (2014) Connectivity of vertebrate genomes: Paired-related homeobox (Prrx) genes in spotted gar, basal teleosts, and tetrapods. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 163:24-36
Amores, A., Catchen, J., Nanda, I., Warren, W., Walter, R., Schartl, M., Postlethwait, J.H. (2014) A RAD-tag Genetic Map for the Platyfish (Xiphophorus maculatus) Reveals Mechanisms of Karyotype Evolution Among Teleost Fish. Genetics. 197(2):625-41
Zigman, M., Laumann-Lipp, N., Titus, T., Postlethwait, J., and Moens, C.B. (2014) Hoxb1b controls oriented cell division, cell shape and microtubule dynamics in neural tube morphogenesis. Development (Cambridge, England). 141(3):639-649
Rodríguez-Marí, A., Cañestro, C., Bremiller, R.A., Catchen, J.M., Yan, Y.L., and Postlethwait, J.H. (2013) Retinoic Acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish. PLoS One. 8(9):e73951
Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Beert, E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius, E., Hopkins, N., and Lees, J.A. (2013) Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genetics. 9(8):e1003734
Meng, F., Braasch, I., Phillips, J.B., Lin, X., Titus, T., Zhang, C., and Postlethwait, J.H. (2013) Evolution of the eye transcriptome under constant darkness in Sinocyclocheilus cavefish. Mol. Biol. Evol.. 30(7):1527-1543
Howe, K., Clark, M.D., Torroja, C.F., Torrance, J., Berthelot, C., Muffato, M., Collins, J.E., Humphray, S., McLaren, K., Matthews, L., McLaren, S., Sealy, I., Caccamo, M., Churcher, C., Scott, C., Barrett, J.C., Koch, R., Rauch, G.J., White, S., Chow, W., Kilian, B., Quintais, L.T., Guerra-Assunção, J.A., Zhou, Y., Gu, Y., Yen, J., Vogel, J.H., Eyre, T., Redmond, S., Banerjee, R., Chi, J., Fu, B., Langley, E., Maguire, S.F., Laird, G.K., Lloyd, D., Kenyon, E., Donaldson, S., Sehra, H., Almeida-King, J., Loveland, J., Trevanion, S., Jones, M., Quail, M., Willey, D., Hunt, A., Burton, J., Sims, S., McLay, K., Plumb, B., Davis, J., Clee, C., Oliver, K., Clark, R., Riddle, C., Eliott, D., Threadgold, G., Harden, G., Ware, D., Mortimer, B., Kerry, G., Heath, P., Phillimore, B., Tracey, A., Corby, N., Dunn, M., Johnson, C., Wood, J., Clark, S., Pelan, S., Griffiths, G., Smith, M., Glithero, R., Howden, P., Barker, N., Stevens, C., Harley, J., Holt, K., Panagiotidis, G., Lovell, J., Beasley, H., Henderson, C., Gordon, D., Auger, K., Wright, D., Collins, J., Raisen, C., Dyer, L., Leung, K., Robertson, L., Ambridge, K., Leongamornlert, D., McGuire, S., Gilderthorp, R., Griffiths, C., Manthravadi, D., Nichol, S., Barker, G., Whitehead, S., Kay, M., Brown, J., Murnane, C., Gray, E., Humphries, M., Sycamore, N., Barker, D., Saunders, D., Wallis, J., Babbage, A., Hammond, S., Mashreghi-Mohammadi, M., Barr, L., Martin, S., Wray, P., Ellington, A., Matthews, N., Ellwood, M., Woodmansey, R., Clark, G., Cooper, J., Tromans, A., Grafham, D., Skuce, C., Pandian, R., Andrews, R., Harrison, E., Kimberley, A., Garnett, J., Fosker, N., Hall, R., Garner, P., Kelly, D., Bird, C., Palmer, S., Gehring, I., Berger, A., Dooley, C.M., Ersan-Ürün, Z., Eser, C., Geiger, H., Geisler, M., Karotki, L., Kirn, A., Konantz, J., Konantz, M., Oberländer, M., Rudolph-Geiger, S., Teucke, M., Osoegawa, K., Zhu, B., Rapp, A., Widaa, S., Langford, C., Yang, F., Carter, N.P., Harrow, J., Ning, Z., Herrero, J., Searle, S.M., Enright, A., Geisler, R., Plasterk, R.H., Lee, C., Westerfield, M., de Jong, P.J., Zon, L.I., Postlethwait, J.H., Nüsslein-Volhard, C., Hubbard, T.J., Crollius, H.R., Rogers, J., and Stemple, D.L. (2013) The zebrafish reference genome sequence and its relationship to the human genome. Nature. 496:498-503
Amemiya, C.T., Alfoldi, J., Lee, A.P., Fan, S., Philippe, H., MacCallum, I., Braasch, I., Manousaki, T., Schneider, I., Rohner, N., Organ, C., Chalopin, D., Smith, J.J., Robinson, M., Dorrington, R.A., Gerdol, M., Aken, B., Biscotti, M.A., Barucca, M., Baurain, D., Berlin, A.M., Blatch, G.L., Buonocore, F., Burmester, T., Campbell, M.S., Canapa, A., Cannon, J.P., Christoffels, A., de Moro, G., Edkins, A.L., Fan, L., Fausto, A.M., Feiner, N., Forconi, M., Gamieldien, J., Gnerre, S., Gnirke, A., Goldstone, J.V., Haerty, W., Hahn, M.E., Hesse, U., Hoffmann, S., Johnson, J., Karchner, S.I., Karaku, S., Lara, M., Levin, J.Z., Litman, G.W., Mauceli, E., Miyake, T., Mueller, M.G., Nelson, D.R., Nitsche, A., Olmo, E., Ota, T., Pallavicini, A., Panji, S., Picone, B., Ponting, C.P., Prohaska, S.J., Przybylski, D., Saha, N.R., Ravi, V., Ribeiro, F.J., Sauka-Spengler, T., Scapigliati, G., Searle, S.M.J., Sharpe, T., Simakov, O., Stadler, P.F., Stegeman, J.J., Sumiyama, K., Tabbaa, D., Tafer, H., Turner-Maier, J., van Heusden, P., White, S., Williams, L., Yandell, M., Brinkmann, H., Volff, J.N., Tabin, C.J., Shubin, N., Schartl, M., Jaffe, D.B., Postlethwait, J.H., Venkatesh, B., Palma, F.D., Lander, E.S., Meyer, A., and Lindblad-Toh, K. (2013) The African coelacanth genome provides insights into tetrapod evolution. Nature. 496:311-316
Yan, Y.L., Bhattacharya, P., He, X., Ponugoti, B., Marquardt, B., Layman, J., Grunloh, M., Postlethwait, J.H., and Rubin, D. (2012) Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis. The Journal of endocrinology. 214(3):421-435
Talbot, J.C., Walker, M.B., Carney, T.J., Huycke, T.R., Yan, Y.L., Bremiller, R.A., Gai, L., Delaurier, A., Postlethwait, J.H., Hammerschmidt, M., and Kimmel, C.B. (2012) fras1 shapes endodermal pouch 1 and stabilizes zebrafish pharyngeal skeletal development. Development (Cambridge, England). 139(15):2804-2813
Delaurier, A., Nakamura, Y., Braasch, I., Khanna, V., Kato, H., Wakitani, S., Postlethwait, J.H., and Kimmel, C.B. (2012) Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Developmental Biology. 12(1):16
Nakamura, Y., He, X., Kato, H., Wakitani, S., Kobayashi, T., Watanabe, S., Iida, A., Tahara, H., Warman, M.L., Watanapokasin, R., and Postlethwait, J.H. (2012) Sox9 Is Upstream of MicroRNA-140 in Cartilage. Applied Biochemistry and Biotechnology. 166(1):64-71
Anderson, J.L., Rodriguez-Mari, A., Braasch, I., Amores, A., Hohenlohe, P., Batzel, P., and Postlethwait, J.H. (2012) Multiple Sex-Associated Regions and a Putative Sex Chromosome in Zebrafish Revealed by RAD Mapping and Population Genomics. PLoS One. 7(7):e40701
Lenhart, K.F., Lin, S.Y., Titus, T.A., Postlethwait, J.H., Burdine, R.D. (2011) Two additional midline barriers function with midline lefty1 expression to maintain asymmetric Nodal signaling during left-right axis specification in zebrafish. Development (Cambridge, England). 138(20):4405-4410
He, X., Yan, Y.L., Eberhart, J.K., Herpin, A., Wagner, T.U., Schartl, M., and Postlethwait, J.H. (2011) miR-196 regulates axial patterning and pectoral appendage initiation. Developmental Biology. 357(2):463-77
Amores, A., Catchen, J., Ferrara, A., Fontenot, Q., and Postlethwait, J.H. (2011) Genome evolution and meiotic maps by massively parallel DNA sequencing: spotted gar, an outgroup for the teleost genome duplication. Genetics. 188(4):799-808
Eames, B.F., Yan, Y.L., Swartz, M.E., Levic, D.S., Knapik, E.W., Postlethwait, J.H., and Kimmel, C.B. (2011) Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation. PLoS Genetics. 7(8):e1002246
Hochheiser, H., Aronow, B.J., Artinger, K., Beaty, T.H., Brinkley, J.F., Chai, Y., Clouthier, D., Cunningham, M.L., Dixon, M., Donahue, L.R., Fraser, S.E., Hallgrimsson, B., Iwata, J., Klein, O., Marazita, M.L., Murray, J.C., Murray, S., de Villena, F.P., Postlethwait, J., Potter, S., Shapiro, L., Spritz, R., Visel, A., Weinberg, S.M., and Trainor, P.A. (2011) The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Developmental Biology. 355(2):175-182
Rodriguez-Mari, A., Wilson, C., Titus, T.A., Cañestro, C., Bremiller, R.A., Yan, Y.L., Nanda, I., Johnston, A., Kanki, J.P., Gray, E.M., He, X., Spitsbergen, J., Schindler, D., and Postlethwait, J.H. (2011) Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish. PLoS Genetics. 7(3):e1001357
Clark, M.D., Guryev, V., Bruijn, E., Nijman, I.J., Tada, M., Wilson, C., Deloukas, P., Postlethwait, J.H., Cuppen, E., and Stemple, D.L. (2011) Single nucleotide polymorphism (SNP) panels for rapid positional cloning in zebrafish. Methods in cell biology. 104:219-235
Nakamura, Y., Yamamoto, K., He, X., Otsuki, B., Kim, Y., Murao, H., Soeda, T., Tsumaki, N., Deng, J.M., Zhang, Z., Behringer, R.R., Crombrugghe, B., Postlethwait, J.H., Warman, M.L., Nakamura, T., and Akiyama, H. (2011) Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nature communications. 2:251
Rodriguez-Mari, A., Cañestro, C., Bremiller, R.A., Nguyen-Johnson, A., Asakawa, K., Kawakami, K., and Postlethwait, J.H. (2010) Sex Reversal in Zebrafish fancl Mutants Is Caused by Tp53-Mediated Germ Cell Apoptosis. PLoS Genetics. 6(7):e1001034
Eames, B.F., Singer, A., Smith, G.A., Wood, Z.A., Yan, Y.L., He, X., Polizzi, S.J., Catchen, J.M., Rodriguez-Mari, A., Linbo, T., Raible, D.W., and Postlethwait, J.H. (2010) UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Developmental Biology. 341(2):400-415
Jovelin, R., Yan, Y.L., He, X., Catchen, J., Amores, A., Canestro, C., Yokoi, H., and Postlethwait, J.H. (2010) Evolution of developmental regulation in the vertebrate FgfD subfamily. Journal of experimental zoology. Part B, Molecular and developmental evolution. 314(1):33-56
Albertson, R.C., Yan, Y.L., Titus, T.A., Pisano, E., Vacchi, M., Yelick, P.C., Detrich, H.W. 3rd, and Postlethwait, J.H. (2010) Molecular pedomorphism underlies craniofacial skeletal evolution in Antarctic notothenioid fishes. BMC Evolutionary Biology. 10:4
Sullivan, C., Charette, J., Catchen, J., Lage, C.R., Giasson, G., Postlethwait, J.H., Millard, P.J., and Kim, C.H. (2009) The Gene History of Zebrafish tlr4a and tlr4b Is Predictive of Their Divergent Functions. Journal of immunology (Baltimore, Md. : 1950). 183(9):5896-5908
Titus, T.A., Yan, Y.L., Wilson, C., Starks, A.M., Frohnmayer, J.D., Canestro, C., Rodriguez-Mari, A., He, X., and Postlethwait, J.H. (2009) The Fanconi anemia/BRCA gene network in zebrafish: Embryonic expression and comparative genomics. Mutation research. 668(1-2):117-132
Yokoi, H., Yan, Y.L., Miller, M.R., Bremiller, R.A., Catchen, J.M., Johnson, E.A., and Postlethwait, J.H. (2009) Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Developmental Biology. 329(1):1-15
Nakamura, Y., He, X., Kobayashi, T., Yan, Y.L., Postlethwait, J.H., and Warman, M.L. (2008) Unique roles of microRNA140 and its host gene WWP2 in cartilage biology. Journal of musculoskeletal & neuronal interactions. 8(4):321-322
Rotllant, J., Liu, D., Yan, Y.L., Postlethwait, J.H., Westerfield, M., and Du, S.J. (2008) Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix biology : journal of the International Society for Matrix Biology. 27(6):561-572
Eberhart, J.K., He, X., Swartz, M.E., Yan, Y.L., Song, H., Boling, T.C., Kunerth, A.K., Walker, M.B., Kimmel, C.B., and Postlethwait, J.H. (2008) MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nature Genetics. 40(3):290-298
Jovelin, R., He, X., Amores, A., Yan, Y.L., Shi, R., Qin, B., Roe, B., Cresko, W.A., and Postlethwait, J.H. (2007) Duplication and divergence of fgf8 functions in teleost development and evolution. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308B(6):730-743
Sakata, S.I., Yan, Y., Satou, Y., Momoi, A., Ngo-Hazelett, P., Nozaki, M., Furutani-Seiki, M., Postlethwait, J.H., Yonehara, S., and Sakamaki, K. (2007) Conserved function of caspase-8 in apoptosis during bony fish evolution. Gene. 396(1):134-148
Sullivan, C., Postlethwait, J.H., Lage, C.R., Millard, P.J., and Kim, C.H. (2007) Evidence for Evolving Toll-IL-1 Receptor-Containing Adaptor Molecule Function in Vertebrates. Journal of immunology (Baltimore, Md. : 1950). 178(7):4517-4527
Miller, M.R., Atwood, T.S., Eames, B.F., Eberhart, J.K., Yan, Y.L., Postlethwait, J.H., and Johnson, E.A. (2007) RAD marker microarrays enable rapid mapping of zebrafish mutations. Genome biology. 8(6):R105
Nolte, C., Rastegar, M., Amores, A., Bouchard, M., Grote, D., Maas, R., Kovacs, E.N., Postlethwait, J., Rambaldi, I., Rowan, S., Yan, Y.L., Zhang, F., and Featherstone, M. (2006) Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. Developmental Biology. 299(2):582-593
Tallafuss, A., Hale, L.A., Yan, Y.L., Dudley, L., Eisen, J.S., and Postlethwait, J.H. (2006) Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development. Gene expression patterns : GEP. 6(5):556-565
Hale, L.A., Tallafuss, A., Yan, Y.L., Dudley, L., Eisen, J.S., and Postlethwait, J.H. (2006) Characterization of the retinoic acid receptor genes raraa, rarab and rarg during zebrafish development. Gene expression patterns : GEP. 6(5):546-555
Bromee, T., Venkatesh, B., Brenner, S., Postlethwait, J.H., Yan, Y.L., and Larhammar, D. (2006) Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages. Gene. 373:100-108
Titus, T.A., Selvig, D.R., Qin, B., Wilson, C., Starks, A.M., Roe, B.A., and Postlethwait, J.H. (2006) The Fanconi anemia gene network is conserved from zebrafish to human. Gene. 371(2):211-223
Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
Kuo, M.W., Postlethwait, J., Lee, W.C., Lou, S.W., Chan, W.K., and Chung, B.C. (2005) Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family. The Biochemical journal. 389(Pt 1):19-26
Rodríguez-Marí, A., Yan, Y.L., Bremiller, R.A., Wilson, C., Cañestro, C., and Postlethwait, J.H. (2005) Characterization and expression pattern of zebrafish anti-Müllerian hormone (amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development. Gene expression patterns : GEP. 5(5):655-667
Gloriam, D.E., Bjarnadóttir, T.K., Yan, Y.L., Postlethwait, J.H., Schiöth, H.B., and Fredriksson, R. (2005) The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish. Molecular phylogenetics and evolution. 35(2):470-482
Yan, Y.L., Willoughby, J., Liu, D., Crump, J.G., Wilson, C., Miller, C.T., Singer, A., Kimmel, C., Westerfield, M., and Postlethwait, J.H. (2005) A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development (Cambridge, England). 132(5):1069-1083
Papasani, M.R., Gensure, R.C., Yan, Y.L., Gunes, Y., Postlethwait, J.H., Ponugoti, B., John, M.R., Jüppner, H., and Rubin, D.A. (2004) Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39 (TIP39). Endocrinology. 145(11):5294-5304
Flores, M.V., Tsang, V.W., Hu, W., Kalev-Zylinska, M., Postlethwait, J., Crosier, P., Crosier, K., and Fisher, S. (2004) Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Gene expression patterns : GEP. 4(5):573-581
Cao, Y., Zhao, J., Sun, Z., Zhao, Z., Postlethwait, J., and Meng, A. (2004) fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Developmental Biology. 271(1):130-143
Naruse, K., Tanaka, M., Mita, K., Shima, A., Postlethwait, J., and Mitani, H. (2004) A Medaka Gene Map: The Trace of Ancestral Vertebrate Proto-Chromosomes Revealed by Comparative Gene Mapping. Genome research. 14(5):820-828
Ruuskanen, J., Xhaard, H., Marjamäki, A., Salaneck, E., Salminen, T., Yan, Y.-L., Postlethwait, J.H., Johnson, M.S., Larhammar, D., and Scheinin, M. (2004) Identification of duplicated fourth {alpha}2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol. Biol. Evol.. 10:14-28
Amores, A., Suzuki, T., Yan, Y.-L., Pomeroy, J., Singer, A., Amemiya, C., and Postlethwait, J.H. (2004) Developmental roles of pufferfish hox clusters and genome evolution in ray-fin fish. Genome research. 14(1):1-10
Postlethwait, J., Ruotti, V., Carvan, M.J., and Tonellato, P.J. (2004) Automated analysis of conserved syntenies for the zebrafish genome. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:255-271
Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V., Postlethwait, J.H., Chau, J.Y., Cattin, P.M., Vitas, M.R., Crosier, P.S., and Crosier, K.E. (2003) Runx3 is required for hematopoietic development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):323-336
Cresko, W.A., Yan, Y.L., Baltrus, D.A., Amores, A., Singer, A., Rodriguez-Mari, A., and Postlethwait, J.H. (2003) Genome duplication, subfunction partitioning, and lineage divergence: Sox9 in stickleback and zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):480-489
Rhinn, M., Lun, K., Amores, A., Yan, Y.-L., Postlethwait, J.H., and Brand, M. (2003) Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling. ZFIN Direct Data Submission.
Rhinn, M., Lun, K., Amores, A., Yan, Y.-L., Postlethwait, J.H., and Brand, M. (2003) Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signaling. Mechanisms of Development. 120(8):919-936
Zhao, C.-T., Shi, K.-H., Su, Y., Liang, L.-Y., Yan, Y.-L, Postlethwait, J., and Meng, A.-M. (2003) Two variants of zebrafish p100 are expressed during embryogenesis and regulated by Nodal signaling. FEBS letters. 543(1-3):190-195
Liu, D., Chu, H., Maves, L., Yan, Y.-L., Morcos, P.A., Postlethwait, J.H., and Westerfield, M. (2003) Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development (Cambridge, England). 130(10):2213-2224
Paw, B.H., Davidson, A.J., Zhou, Y., Li, R., Pratt, S.J., Lee, C., Trede, N.S., Brownlie, A., Donovan, A., Liao, E.C., Ziai, J.M., Drejer, A.H., Guo, W., Kim, C.H., Gwynn, B., Peters, L.L., Chernova, M.N., Alper, S.L., Zapata, A., Wickramasinghe, S.N., Lee, M.J., Lux, S.E., Fritz, A., Postlethwait, J.H., and Zon, L.I. (2003) Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nature Genetics. 34(1):59-64
Masumoto, J., Zhou, W., Chen, F.F., Su, F., Kuwada, J.Y., Hidaka, E., Katsuyama, T., Sagara, J., Taniguchi, S., Ngo-Hazelett, P., Postlethwait, J.H., Nuñez, G., and Inohara, N. (2003) Caspy: A Zebrafish caspase activated by ASC oligomerization required for pharyngeal arch development. The Journal of biological chemistry. 278(6):4268-4276
Yan, Y.-L., Miller, C.T., Nissen, R.M., Singer, A., Liu, D., Kirn, A., Draper, B., Willoughby, J., Morcos, P.A., Amsterdam, A., Chung, B.-C., Westerfield, M., Haffter, P., Hopkins, N., Kimmel, C., and Postlethwait, J.H. (2002) A zebrafish sox9 gene required for cartilage morphogenesis. Development (Cambridge, England). 129(21):5065-5079
Pratt, S.J., Drejer, A., Foott, H., Barut, B., Brownlie, A., Postlethwait, J., Kato, Y., Yamamoto, M., and Zon, L.I. (2002) Isolation and characterization of zebrafish NFE2. Physiological Genomics. 11(2):91-98
Canfield, V.A., Loppin, B., Thisse, B., Thisse, C., Postlethwait, J.H., Mohideen, A.P.K., Rajarao, S.J.R., and Levenson, R. (2002) Na,K-ATPase alpha and beta subunit genes exhibit unique expression patterns during zebrafish embryogenesis. Mechanisms of Development. 116(1-2):51-59
Ringholm, A., Fredriksson, R., Poliakova, N., Yan, Y.-L., Postlethwait, J.H., Larhammar, D., and Schiöth, H.B. (2002) One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. Journal of neurochemistry. 82(1):6-18
Dunér, T., Conlon, J.M., Kukkonen, J.P., Akerman, K.E.O., Yan, Y.-L., Postlethwait, J.H., and Larhammar, D. (2002) Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor. The Biochemical journal. 364(3):817-824
Kalev-Zylinska, M.L., Horsfield, J.A., Flores, M.V.C., Postlethwait, J.H., Vitas, M.R., Baas, A.M., Crosier, P.S., and Crosier, K.E. (2002) Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis. Development (Cambridge, England). 129(8):2015-2030
Rajarao, J.R., Canfield, V.A., Loppin, B., Thisse, B., Thisse, C., Yan, Y.-L., Postlethwait, J.H., and Levenson, R. (2002) Two Na,K-ATPase beta 2 subunit isoforms are differentially expressed within the central nervous system and sensory organs during zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 223(2):254-261
Singer, A., Perlman, H., Yan, Y.-L., Walker, C., Corley-Smith, G., Brandhorst, B., and Postlethwait, J. (2002) Sex-specific recombination rates in zebrafish (Danio rerio). Genetics. 160(2):649-657
Willot, V., Mathieu, J., Lu, Y., Schmid, B., Sidi, S., Yan, Y.-L., Postlethwait, J.H., Mullins, M., Rosa, F., and Peyriéras, N. (2002) Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. Developmental Biology. 241(1):59-78
Henry, C.A., Crawford, B.D., Yan, Y.-L., Postlethwait, J., Cooper, M.S., and Hille, M.B. (2001) Roles for zebrafish focal adhesion kinase in notochord and somite morphogenesis. Developmental Biology. 240(2):474-487
Crosier, P.S., Bardsley, A., Horsfield, J.A., Krassowska, A.K., Lavallie, E.R., Collins-Racie, L.A., Postlethwait, J.H., Yan, Y.-L., McCoy, J.M., and Crosier, K.E. (2001) In situ hybridization screen in zebrafish for the selection of genes encoding secreted proteins. Developmental Dynamics : an official publication of the American Association of Anatomists. 222(4):637-644
Chiang, E.F.L., Yan, Y.L., Tong, S.K., Hsiao, P.H., Guiguen, Y., Postlethwait, J., and Chung, B.C. (2001) Characterization of duplicated zebrafish cyp19 genes. The Journal of experimental zoology. 290(7):709-714
Kalev, M.L., Horsfield, J.A., Flores, M.C., Postlethwait, J.H., Vitas, M.R., Baas, A.M., Crosier, P.S., and Crosier, K.E. (2001) Runt family transcription factors are required for zebrafish hematopoiesis, and their function is disrupted by a human RUNX1-CBF2T1 transgene. Blood. 98(11):1892
Oates, A.C., Pratt, S.J., Vail, B., Yan, Y.-L., Ho, R.K., Johnson, S.L., Postlethwait, J.H., and Zon, L.I. (2001) The zebrafish klf gene family. Blood. 98(6):1792-1801
Varga, Z.M., Amores, A., Lewis, K.E., Yan, Y.-L., Postlethwait, J.H., Eisen, J.S., and Westerfield, M. (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development (Cambridge, England). 128(18):3497-3509
Topczewski, J., Sepich, D.S., Myers, D.C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J., and Solnica-Krezel, L. (2001) The zebrafish glypican Knypek controls cell polarity during gastrulation movements of convergent extension. Developmental Cell. 1(2):251-264
Rajarao, S.J., Canfield, V.A., Mohideen, M.A., Yan, Y.-L., Postlethwait, J.H., Cheng, K.C., and Levenson, R. (2001) The repertoire of Na,K-ATPase alpha and beta subunit genes expressed in the zebrafish, Danio rerio. Genome research. 11(7):1211-1220
Chiang, E., Pai, C.-I., Wyatt, M., Yan, Y-L., Postlethwait, J., and Chung, B.-C. (2001) Two sox9 genes on duplicated zebrafish chromosomes: expression of similar transcription activators in distinct sites. Developmental Biology. 229:149-163
Bertrand, C., Chatonnet, A., Takke, C., Yan, Y.-L., Postlethwait, J., Toutant, J.P., and Cousin, X. (2001) Zebrafish Acetylcholinesterase Is Encoded by a Single Gene Localized on Linkage Group 7: Gene structure and polymorphism; molecular forms and expression pattern during development. The Journal of biological chemistry. 276(1):464-474
Postlethwait, J.H., Woods, I.G., Ngo-Hazelett, P., Yan, Y.-L., Kelly, P.D., Chu, F., Huang, H., Hill-Force, A., and Talbot, W.S. (2000) Zebrafish comparative genomics and the origins of vertebrate chromosomes. Genome research. 10(12):1890-1902
Woods, I.G., Kelly, P.D., Chu, F., Ngo-Hazelett, P., Yan, Y.-L., Huang, H., Postlethwait, J.H., and Talbot, W.S. (2000) A comparative map of the zebrafish genome. Genome research. 10(12):1903-1914
Liao, W., Ho, C.Y., Yan, Y.L., Postlethwait, J., and Stainier, D.Y.R. (2000) Hhex and Scl function in parallel to regulate early endothelial and blood differentiation in zebrafish. Development (Cambridge, England). 127(20):4303-4313
Söderberg, C., Wraith, A., Ringvall, M., Yan, Y.-L., Postlethwait, J.H., Brodin, L., and Larhammar, D. (2000) Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster. Journal of neurochemistry. 75(3):908-918
Kelly, P.D., Chu, F., Woods, I.G., Ngo-Hazelett, P., Cardozo, T., Huang, H., Kimm, F., Liao, L., Yan, Y.L., Zhou, Y., Johnson, S.L., Abagyan, R., Schier, A.F., Postlethwait, J.H., and Talbot, W.S. (2000) Genetic linkage mapping of zebrafish genes and ESTs. Genome research. 10(4):558-567
De Martino, S., Yan, Y.-L., Jowett, T., Postlethwait, J.H., Varga, Z.M., Ashworth, A., and Austin, C.A. (2000) Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development. Developmental Dynamics : an official publication of the American Association of Anatomists. 217(3):279-292
Brand, M., Lun, K., Reifers, F., Thisse, B., Thisse, C., Amores, A., Yan, Y.-L., and Postlethwait, J. (2000) Subdivision of the early zebrafish neural primordium in response to posteriorizing signals. The European journal of neuroscience. 12:60
O'Brien, S.J., Eisenberg, J.F., Miyamoto, M., Hedges, S.B., Kumar, S., Wilson, D.E., Menotti-Raymond, M., Murphy, W.J., Nash, W.G., Lyons, L.A., Menninger, J.C., Stanyon, R., Wienberg, J., Copeland, N.G., Jenkins, N.A., Gellin, J., Yerle, M., Andersson, L., Womack, J., Broad, T., Postlethwait, J., Serov, O., Bailey, E., James, M.R., and Marshall Graves, J.A. (1999) Genome maps 10. Comparative genomics. Mammalian radiations. Wall chart. Science (New York, N.Y.). 286:463-478
Hukriede N,A., Joly, L., Tsang, M., Miles, J., Tellis, P., Epstein, J.A., Barbazuk, W.B., Li, F.N., Paw, B., Postlethwait, J.H., Hudson, T.J., Zon, L.I., McPherson, J.D., Chevrette, M., Dawid, I.B., Johnson, S.L., and Ekker, M. (1999) Radiation hybrid mapping of the zebrafish genome. Proceedings of the National Academy of Sciences of the United States of America. 96(17):9745-9750
Starbäck, P., Lundell, I., Fredriksson, R., Berglund, M.M., Yan, Y.-L., Wraith, A., Söderberg, C., Postlethwait, J.H., and Larhammar, D. (1999) Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor. Mol. Brain Res.. 70(2):242-252
Delot, E., Kataoka, H., Goutel, C., Yan, Y.L., Postlethwait, J., Wittbrodt, J., and Rosa, F.M. (1999) The BMP-related protein Radar: a maintenance factor for dorsal neuroectoderm cells?. Mechanisms of Development. 85(1-2):15-25
Force, A., Lynch, M., Pickett, F.B., Amores, A., Yan, Y.-L., and Postlethwait, J. (1999) Preservation of duplicate genes by complementary, degenerative mutations. Genetics. 151:1531-1545
Davidson, A.J., Postlethwait, J.H., Yan, Y.-L., Beier, D.R., Van Doren, C., Förnzler, D., Celeste, A.J., Crosier, K.E., and Crosier, P.S. (1999) Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily. Genome research. 9:121-129
Postlethwait, J.H., Yan, Y.-L., and Gates, M.A. (1999) Using random amplified polymorphic DNAs in zebrafish genomic analysis. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:165-179
Amores, A. and Postlethwait, J.H. (1999) Banded chromosomes and the zebrafish karyotype. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:323-338
Postlethwait, J., Amores, A., Force, A., and Yan, Y.-L. (1999) The zebrafish genome. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:149-163
Risinger, C., Salaneck, E., Söderberg, C., Gates, M., Postlethwait, J.H., and Larhammar, D. (1998) Cloning of two loci for synapse protein Snap25 in zebrafish: Comparison of paralogous linkage groups suggests loss of one locus in the mammalian lineage. Journal of neuroscience research. 54(5):563-573
Amores, A., Force, A., Yan, Y.-L. Joly, L., Amemiya, C., Fritz, A., Ho, R., Langeland, J., Prince, V., Wang, Y.-L., Westerfield, M., Ekker, M., and Postlethwait, J.H. (1998) Zebrafish hox clusters and vertebrate genome evolution. Science (New York, N.Y.). 282:1711-1714
Förnzler, D., Her, H., Knapik, E.W., Clark, M., Lehrach, H., Postlethwait, J.H., Zon, L.I., Beier, D.R. (1998) Gene mapping in zebrafish using single-strand conformation polymorphism analysis. Genomics. 51:216-222
Thompson, M.A., Ransom, D.G., Pratt, S.J., MacLennan, H., Kieran, M.W., Detrich,III, H.W., Vail, B., Huber, T.L., Paw, B., Brownlie, A.J., Oates, A.C., Fritz, A., Gates, MA., Amores, A., Bahary, N., Talbot, W.S., Her, H., Beier, D.R., Postlethwait, J.H., and Zon, L.I. (1998) The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Developmental Biology. 197:248-269
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genetics. 18:345-349
Liao, E.C., Paw, B.H., Oates, A.C., Pratt, S.J., Postlethwait, J.H., and Zon, L.I. (1998) SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish. Genes & Development. 12:621-626
Talbot, W.S., Egan, E.S., Gates, M.A., Walker, C., Ullmann, B., Neuhauss, S.C.F., Kimmel, C.B., and Postlethwait, J.H. (1998) Genetic analysis of chromosomal rearrangements in the cyclops region of the zebrafish genome. Genetics. 148:373-380
Lee, K.H., Marden, J.J., Thompson, M.S., MacLennan, H., Kishimoto, Y., Pratt, S.J., Schulte-Merker, S., Hammerschmidt, M., Johnson, S.L., Postlethwait, J.H., Beier, D.C., and Zon, L.I. (1998) Cloning and genetic mapping of zebrafish BMP-2. Developmental genetics. 23:97-103
Halpern, M.E., Hatta, K., Amacher, S.L., Talbot, W.S., Yan, Y.-L., Thisse, B., Thisse, C., Postlethwait, J.H., and Kimmel, C.B. (1997) Genetic interactions in zebrafish midline development. Developmental Biology. 187(2):154-170
Bingulac-Popovic, J., Figueroa, F., Sato, A., Talbot, W.S., Johnson, S.L., Gates, M., Postlethwait, J.H., and Klein, J. (1997) Mapping of Mhc class I and class II regions to different linkage groups in the zebrafish, Danio rerio. Immunogenetics. 46(2):129-134
Johnson, S.L., Gates, M.A., Johnson, M., Talbot, W.S., Horne, S., Baik, K., Rude, S., Wong, J.R., and Postlethwait, J.H. (1996) Centromere-linkage analysis and consolidation of the zebrafish genetic map. Genetics. 142:1277-1288
Halpern, M.E., Thisse, C., Ho, R.K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E.S., Postlethwait, J.H., and Kimmel, C.B. (1995) Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants. Development (Cambridge, England). 121:4257-4264
Talbot, W.S., Trevarrow, B., Halpern, M.E., Melby, A.E., Farr, G., Postlethwait, J.H., Jowett, T., Kimmel, C.B., and Kimelman, D. (1995) A homeobox gene essential for zebrafish notochord development. Nature. 378:150-157
Postlethwait, J., Johnson, S., Midson, C.N., Talbot, W.S., Gates, M., Ballenger, E.W., Africa, D., Andrews, R., Carl, T., Eisen, J.S., Horne, S., Kimmel, C.B., Hutchinson, M., Johnson, M., and Rodriguez, A. (1994) A genetic linkage map for the zebrafish. Science (New York, N.Y.). 264:699-703
NON-ZEBRAFISH PUBLICATIONS
Bassham, S. and J. Postlethwait (2000) Brachyury (T) expression in embryos of a larvacean urochordate, Oikopleura dioica, and the ancestral role of brachyury. Dev. Biol. 220:322-332.
Schofield, R.M.S., J.H. Postlethwait, and H.W. Lefevre (1997) MeV-ion microprobe analyses of whole Drosophila suggest that zinc and copper accumulation is regulated storage not deposit excretion. J. Exp. Biol. 200:3235-3243.
Postlethwait, J.H. and J. Hopson (1992) The Nature of Life. McGraw-Hill: New York, 700 pp. (An introductory biology textbook for non-biology majors).
Postlethwait, J.H., J. Hopson, and R. Veres (1991) Biology! Bringing Science to Life McGraw-Hill Publishing: New York, 600 pp. (An introductory biology textbook for non-biology majors at community colleges).
Yan, Y.-L. and J.H. Postlethwait (1990) Vitellogenesis in Drosophila: Sequestration of a yolk polypeptide/invertase fusion protein into developing oocytes. Devel. Biol. 140:281-290.
Postlethwait, J.H., S. Saul, and J.A. Postlethwait (1988) The antibacterial immune response of the Mediterranean fruit fly (Certatitis capitata). J. Insect Physiol. 34:91-96.
Postlethwait, J.H., C. Kunert, J. Parker, D. Widders-Ellis, and Y. Yan (1987) Regulation of vitellogenesis in Drosophila. In Invertebrate Reproduction, M. Porchet and A. Strombi, eds., Elsevier Press. 4:23-30.
Postlethwait, J.H. and J. Parker (1987) Regulation of vitellogenesis in Drosophila. UCLA Symposia on Molecular and Cellular Biology, J. D. O'Connor, ed. Molec. Biol. Invert. Devel. 66:29-42.
Postlethwait, J.H. (1987) Hormone and sex-specific gene regulation in Drosophila. In Proceedings of the 1st Congress of the Asia and Oceania Society for Comparative Endocrinology, Nagoya, Japan. 2:11-14.
Postlethwait, J.H., S. Saul, M. Robertson, D. Grace, K. Abrams, and E. Brandenburg (1987) Mechanisms of Immunity in Drosophila and Mediterranean Fruit Flies. ACS Symposium Series. In Biotechnology in Crop Protection, ACS Publications, Washington D.C., pp. 186-198.
Giorgi, F., P. Andolfi, I. Spinetti, M. Masetti, and J.H. Postlethwait (1986) In Vivo uptake of haemolymph from a female sterile mutant into wild-type ovaries of Drosophila melanogaster. J. Insect Physiol. 32:59-70.
Postlethwait, J.H., and C. Kunert (1986) Endocrine and Genetic Regulation of Vitellogenesis in Drosophila. In Comparative Endocrinology: Development and Direction. Progress in Clinical and Biological Research, Vol.X, C.L. Ralph, ed., Alan R. Liss, New York. pp. 33-52.
Robertson, M., and J.H. Postlethwait (1986) The humoral antibacterial response of Drosophila adults. Devel. Compar. Immunol. 10:167-179.
Yan, Y.-L., C. Kunert, and J.H. Postlethwait (1986) Sequence homologies among the Three Yolk Polypeptide (Yp) genes in Drosophila melanogaster. Nucl. Acids Res. 15:67-85.
Minoo, P., and J.H. Postlethwait (1985) Biosynthesis of Drosophila yolk polypeptides. Arch. Insect Biochem. and Physiol. 2:7-27.
Postlethwait, J.H., and F. Giorgi (1985) Vitellogenesis: Insects. In Developmental Biology: A Comprehensive Synthesis. L.W. Browder, ed., Plenum Publ.
Giorgi, F., and J.H. Postlethwait (1985) Development of gap junctions in normal and mutant ovaries of Drosophila melanogaster. J. Morphol. 185:115-129.
Johns, M.A., and J.H. Postlethwait (1985) Naturally occurring quantitative variants of acid phosphatase-1 in Drosophila melanogaster. Biochem. Genet. 23:468-482.
Giorgi, F., and J.H. Postlethwait (1985) Yolk polypeptide secretion and vitelline membrane deposition in a female sterile Drosophila mutant. Devel. Genet, 86:133-150.
Tamura, T., C. Kunert, and J.H. Postlethwait (1985) Sex and cell-specific regulation of two yolk polypeptide genes introduced into Drosophila by P-element-mediated gene transfer. P.N.A.S. 82:7000-7004.
Minoo, P., and J.H. Postlethwait (1985) Processing and secretion of a mutant yolk polypeptide in Drosophila. Biochem. Genet. 23:913-932.
Zhai, Q.H., J.H. Postlethwait, and J.W. Bodley (1984) Vitellogenin synthesis in the lady beetle Coccinella septempunctata. Insect Biochem. 14:299-305.
Shirk, P.D., P. Minoo, and J.H. Postlethwait (1983) 20-hydroxyecdysone stimulates the acumulation of translatable yolk polypeptide gene transcript in adult male Drosophila melanogaster. Proc. Natl. Acad. Sci. USA. 80:186-190.
Jowett, T., J.H. Postlethwait, and D.B. Roberts (1982) Hormonal regulation of a larval haemolymph protein in Drosophila. Embryonic Development, Part A: Genetic Aspects. pp. 373-380. Alan R. Liss, New York.
Jowett, T., and J.H. Postlethwait (1981) Hormonal regulation of synthesis of yolk proteins and a larval serum protein (LsP2) in Drosophila. Nature. 292:633-635.
Postlethwait, J.H., and T. Jowett (1981) Regulation of vitellogenesis in Drosophila. Scientific Papers of the Institute of Organic and Physical Chemistry of Wroclas Technical University, No. 22 Conference 7, pp. 591-627.
Postlethwait, J.H., and P.D. Shirk (1981) Genetic and endocrine regulation of vitellogenesis in Drosophila. Am. Zool. 21:687-700.
Postlethwait, J.H., G. Lauge, and A.M. Handler (1980) Yolk protein synthesis in ovariectomized and genetically agametic (X87) Drosophila melanogaster. Gen. Comp. Endocrinol. 40:385-390.
Postlethwait, J.H., M. Bownes, and T. Jowett (1980) Sexual phenotype and vitellogenin synthesis in Drosophila melanogaster. Devel. Biol. 79:379-387.
Jowett, T., and J.H. Postlethwait (1980) The regulation of yolk polypeptide synthesis in Drosophila ovaries and fat body by 20-hydroxecdysone and a juvenile hormone analogue. Dev. Biol. 80:225-234.
Postlethwait, J.H. (1980) Genetic analysis of Drosophila vitellogenesis: A molecular weight varient of yolk polypeptide-2 in Drosophila simulans. Molec. Gen. Genet. 178:253-260.
Postlethwait, J.H. and T. Jowett (1980) Genetic analysis of the hormonally regulated yolk polypeptide genes in D. melanogaster. Cell 20:671-678.
Postlethwait, J.H. (1979) Clonal analysis of Drosophila cuticular patterns. In Genetics and Biology of Drosophila, Vol. 2C, Ashburner and Wright, eds., Academic Press: London, pp. 359-442.
Postlethwait, J.H. and A.M. Handler (1979) The roles of juvenile hormone and ecdysterone during vitellogenesis in isolated abdomens of Drosophila melanogaster. J. Insect Physiol. 25:455-460.
Postlethwait, J.H. and G.J. Jones (1978) Endocrine control of larval fat body histolysis in normal and mutant Drosophila melanogaster. J. Exp. Zool. 203:207-214.
Handler, A.M. and J.H. Postlethwait (1978) Regulation of vitellogenin synthesis in Drosophila by ecdysterone and juvenile hormone. J. Exp. Zool. 206:247-254.
Postlethwait, J.H. (1978) Development of cuticular patterns in legs of a cell lethal mutant of Drosophila melanogaster. Wilhelm Roux's Archiv. 185:37-57.
Postlethwait, J.H. and R. Kaschnitz (1978) The synthesis of Drosophila melanogaster vitellogenins in vivo, in culture and in a cell-free translation system. FEBS Lett. 95:247-251.
Postlethwait, J.H. and A.M. Handler (1978) Nonvitellogenic female sterile mutants and the regulation of vitellogenesis in Drosophila melanogaster. Dev. Biol. 67:202-213.
Handler, A.M. and J.H. Postlethwait (1977) Endocrine control of vitellogenesis in Drosophila melanogaster: Effects of the brain and corpus allatum. J. Exp. Zool. 202:389-401.
Postlethwait, J.H., A.M. Handler, and P.W. Gray (1976) A genetic approach to the study of juvenile hormone control of vitellogenesis in Drosophila melanogaster. In The Juvenile Hormones, Gilbert, L., ed., Plenum Press: New York, pp. 449-469.
Postlethwait, J.H. (1975) Pattern formation in the wing and haltere imaginal discs after irradiation of Drosophila melanogaster first instar larvae. Wilhelm Roux's Arch. 178:29-50.
Postlethwait, J.H. and P. Gray (1975) Regulation of acid phosphatase activity in the ovary of Drosophila melanogaster. Dev. Biol. 47:196-205.
Postlethwait, J.H. (1974) Development of the temperature-sensitive homoeotic mutant Ophthalmoptera of Drosophila melanogaster. Dev. Biol. 36:212-217.
Postlethwait, J.H. and J.R. Girton (1974) Development in genetic mosaics of Aristapedia, a homoeotic mutant of Drosophila melanogaster. Genetics 76:767-774.
Postlethwait, J.H. (1974) Juvenile hormone and the adult development of Drosophila. Biol. Bull. 147:119-135.
Postlethwait, J.H. and H.A. Schneiderman (1973) Pattern formation in imaginal discs of Drosophila melanogaster after irradiation of embryos and young larvae. Dev. Biol. 32:345-360.
Guerra, M., J.H. Postlethwait, and H.A. Schneiderman (1973) The development of the imaginal abdomen of Drosophila melanogaster. Dev. Biol. 32:361-372.
Postlethwait, J.H. and K. Weiser (1973) Vitellogenesis induced by juvenile hormone in the female sterile mutant ap4 of Drosophila melanogaster. Nature New Biol. 244:284-285.
Postlethwait, J.H. and H.A. Schneiderman (1973) Developmental genetics of Drosophila imaginal discs. Ann. Rev. Genet. 7:381-483.
Postlethwait, J.H. (1973) A quantitative juvenile hormone assay on Drosophila. DIS 50:135-138.
Postlethwait, J.H. (1973) Effects of juvenile endocrine organs and juvenile hormone on the metamorphosis of Drosophila. DIS 50:174-176.
Postlethwait, J.H. (1973) Molting of Drosophila first instar cuticle induced by a metamorphosing host. DIS 50:186-187.
Postlethwait, J.H., P.J. Bryant, and G. Schubiger (1972) The homoeotic effect of "Tumorous Head" in Drosophila melanogaster. Dev. Biol. 29:337-342.
Postlethwait, J.H. and H.A. Schneiderman (1971) A clonal analysis of development in Drosophila melanogaster: Morphogenesis, determination and growth in the wild-type antenna. Dev. Biol. 24:477-519.
Postlethwait, J.H. and H.A. Schneiderman (1971) Pattern formation and determination in the antenna of the homoeotic mutant, Antennapedia of Drosophila melanogaster. Dev. Biol. 25:606-640.
Postlethwait, J.H., C.A. Poodry, and H.A. Schneiderman (1971) Cellular dynamics of pattern duplication in imaginal discs of Drosophila melanogaster cultured in vivo. Dev. Biol. 26:125-132.
Postlethwait, J.H. and H.A. Schneiderman (1970) Induction of metamorphosis by ecdysone analogues: Drosophila imaginal discs cultured in vivo. Biol. Bull. 138:47-55.
Postlethwait, J.H. and H.A. Schneiderman (1969) A clonal analysis of determination in Antennapedia, a homoeotic mutant of Drosophila melanogaster. PNAS 61:176-183.
