PUBLICATION
Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers
- Authors
- Desvignes, T., Robbins, A.E., Carey, A.Z., Bailon-Zambrano, R., Nichols, J.T., Postlethwait, J.H., Stankunas, K.
- ID
- ZDB-PUB-220412-15
- Date
- 2022
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 251(8): 1306-1321 (Journal)
- Registered Authors
- Desvignes, Thomas, Nichols, James Tucker, Postlethwait, John H., Stankunas, Kryn
- Keywords
- actinopterygian, caudal fin, fin rays, fin symmetry, hypural diastema, teleosts
- MeSH Terms
-
- Animal Fins/anatomy & histology
- Animals
- Animals, Genetically Modified
- Biological Evolution
- Diastema*
- Zebrafish*/anatomy & histology
- PubMed
- 35403297 Full text @ Dev. Dyn.
Citation
Desvignes, T., Robbins, A.E., Carey, A.Z., Bailon-Zambrano, R., Nichols, J.T., Postlethwait, J.H., Stankunas, K. (2022) Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1306-1321.
Abstract
Background Caudal fin symmetry characterizes teleosts and likely contributes to their evolutionary success. However, the coordinated development and patterning of skeletal elements establishing external symmetry remains incompletely understood. We explore the spatiotemporal emergence of caudal skeletal elements in zebrafish to consider evolutionary and developmental origins of caudal fin symmetry.
Results Transgenic reporters and skeletal staining reveal that the hypural diastema-defining gap between hypurals 2 and 3 forms early and separates progenitors of two plates of connective tissue. Two sets of central principal rays (CPRs) synchronously, sequentially, and symmetrically emerge around the diastema. The two dorsal- and ventral-most rays (peripheral principal rays, PPRs) arise independently and earlier than adjacent CPRs. Muscle and tendon markers reveal that different muscles attach to CPR and PPR sets.
Conclusions We propose that caudal fin symmetry originates from a central organizer that establishes the hypural diastema and bi-directionally patterns surrounding tissue into two plates of connective tissue and two mirrored sets of CPRs. Further, two peripheral organizers unidirectionally specify PPRs, forming a symmetric "composite" fin derived from three fields. Distinct CPR and PPR ontogenies may represent developmental modules conferring ray identities, muscle connections, and biomechanical properties. Our model contextualizes mechanistic studies of teleost fin morphological variation. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping