ZFIN Person: Nichols, James Tucker

ZFIN ID: ZDB-PERS-110706-1

ZFIN ID: ZDB-PERS-110706-1

Nichols, James Tucker

Email:	james.nichols@ucdenver.edu
URL:
Affiliation:	Nichols Lab
Address:	University of Colorado-Anschutz Medical Campus Department of Craniofacial Biology 12801 E. 17th Ave RC-1 South, 11th floor RM 11104 USA
Country:
Phone:	(303) 724-0157
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

2023-present: Associate Professor, University of Colorado-Anschutz Medical Campus
2016-2023: Assistant Professor, University of Colorado-Anschutz Medical Campus
2009-2016: Postdoc, University of Oregon, Kimmel Lab
2001-2008: Graduate Student, UCLA, Weinmaster Lab
1994-1998: Undergraduate, UCSB

PUBLICATIONS

Stenzel, A., Mumme-Monheit, A., Sucharov, J., Walker, M., Mitchell, J.M., Appel, B., Nichols, J.T. (2022) Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning. Frontiers in endocrinology. 13:10338431033843

Bailon-Zambrano, R., Sucharov, J., Mumme-Monheit, A., Murry, M., Stenzel, A., Pulvino, A.T., Mitchell, J.M., Colborn, K.L., Nichols, J. (2022) Variable paralog expression underlies phenotype variation. eLIFE. 11:

Desvignes, T., Robbins, A.E., Carey, A.Z., Bailon-Zambrano, R., Nichols, J.T., Postlethwait, J.H., Stankunas, K. (2022) Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1306-1321

Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):

Tessadori, F., de Bakker, D.E.M., Barske, L., Nelson, N., Algra, H.A., Willekers, S., Nichols, J.T., Crump, J.G., Bakkers, J. (2020) Zebrafish prrx1a mutants have normal hearts. Nature. 585:E14-E16

Kimmel, C.B., Wind, A.L., Oliva, W., Ahlquist, S.D., Walker, C., Dowd, J., Blanco-Sánchez, B., Titus, T.A., Batzel, P., Talbot, J.C., Postlethwait, J.H., Nichols, J.T. (2020) Transgene-mediated skeletal phenotypic variation in zebrafish. Journal of Fish Biology. 98(4):956-970

Sucharov, J., Ray, K., Brooks, E.P., Nichols, J.T. (2019) Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway. PLoS Genetics. 15:e1008507

Brooks, E.P., Nichols, J.T. (2017) Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing. Journal of visualized experiments : JoVE. (127)

Nichols, J.T., Blanco-Sánchez, B., Brooks, E.P., Parthasarathy, R., Dowd, J., Subramanian, A., Nachtrab, G., Poss, K.D., Schilling, T.F., Kimmel, C.B. (2016) Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development (Cambridge, England). 143(23):4430-4440

Talbot, J.C., Nichols, J.T., Yan, Y.L., Leonard, I.F., BreMiller, R.A., Amacher, S.L., Postlethwait, J.H., Kimmel, C.B. (2016) Pharyngeal morphogenesis requires fras1-itga8- dependent epithelial-mesenchymal interaction. Developmental Biology. 416(1):136-48

Barske, L., Askary, A., Zuniga, E., Balczerski, B., Bump, P., Nichols, J.T., Crump, J.G. (2016) Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genetics. 12:e1005967

Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813

Delaurier, A., Huycke, T.R., Nichols, J.T., Swartz, M.E., Larsen, A., Walker, C., Dowd, J., Pan, L., Moens, C.B., and Kimmel, C.B. (2014) Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Developmental Biology. 385(2):189-99

Nichols, J.T., Pan, L., Moens, C.B., and Kimmel, C.B. (2013) barx1 represses joints and promotes cartilage in the craniofacial skeleton. Development (Cambridge, England). 140(13):2765-2775

Sasaki, M.M., Nichols, J.T., and Kimmel, C.B. (2013) edn1 and hand2 Interact in Early Regulation of Pharyngeal Arch Outgrowth during Zebrafish Development. PLoS One. 8(6):e67522

Eames, B.F., Delaurier, A., Ullmann, B., Huycke, T.R., Nichols, J.T., Dowd, J., McFadden, M., Sasaki, M.M., and Kimmel, C.B. (2013) FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution. BMC Developmental Biology. 13(1):23

NON-ZEBRAFISH PUBLICATIONS
Charles B. Kimmel, Sawyer Watson, Ryan B. Couture, Natasha S. McKibben, James T. Nichols, Shannon E. Richardson and David L. G. Noakes. Patterns of variation and covariation in the shapes of mandibular bones of juvenile salmonids in the genus Oncorhynchus. Evolution & Development. 2015

James T. Nichols, Gerry Weinmaster. Proteolytic activation of Notch signaling: Roles for ligand endocytosis and mechanotransduction (Book Chapter). Handbook of Cell Signaling. 2008

James T. Nichols, Alison Miyamoto, Gerry Weinmaster. Notch Signaling-constantly on the move (Review). Traffic. 2007 Aug 8; (8):959-69.

James T. Nichols, Alison Miyamoto, Samantha L. Olsen, Brendan D’Souza, Christine Yao, and Gerry Weinmaster. DSL-ligand Endocytosis Physically Dissociates Notch1 Heterodimers Before Activating Proteolysis Can Occur. Journal of Cell Biology. 2007 Feb 12; 176(4):445-58.

Ena Ladi, James T. Nichols, Alison Miyamoto, Jim Boulter, Weihong Ge, Liang-Tung Yang, Yi E. Sun, Chris Kintner and Gerry Weinmaster. The Divergent DSL Ligand Dll3 Cannot Activate Notch Signaling but Cell Autonomously Attenuates Signaling Induced by Other DSL Ligands. Journal of Cell Biology. 2005 Sep 12;170(6):983-92.

T Haritunians, T Chow, R P J De Lange, James T. Nichols, D Ghavimi, N Dorrani, D M St Clair, G Weinmaster, C Schanen. Functional analysis of a recurrent missense mutation in Notch3 in CADASIL. Journal of Neurology, Neurosurgery, and Psychiatry. 2005 Sep;76(9):1242-8

Liang-Tung Yang, James T. Nichols, Christine Yao, Jennifer O. Manilay, Ellen A. Robey, and Gerry Weinmaster. Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1. Molecular Biology of the Cell. 2005 Feb;16(2):927-42.