ZFIN ID: ZDB-PERS-110706-1
Nichols, James Tucker
Email: james.nichols@ucdenver.edu
Affiliation: Nichols Lab
Address: University of Colorado-Anschutz Medical Campus Department of Craniofacial Biology 12801 E. 17th Ave RC-1 South, 11th floor RM 11104 USA
Phone: (303) 724-0157

2016-current: Assistant Professor, University of Colorado Denver-Anschutz Medical Campus
2009-2016: Postdoc, University of Oregon, Kimmel Lab
2001-2008: Graduate Student, UCLA, Weinmaster Lab
1994-1998: Undergraduate, UCSB

Desvignes, T., Robbins, A.E., Carey, A.Z., Bailon-Zambrano, R., Nichols, J.T., Postlethwait, J.H., Stankunas, K. (2022) Coordinated patterning of zebrafish caudal fin symmetry by a central and two peripheral organizers. Developmental dynamics : an official publication of the American Association of Anatomists. 251(8):1306-1321
Mitchell, J.M., Sucharov, J., Pulvino, A.T., Brooks, E.P., Gillen, A.E., Nichols, J.T. (2021) The alx3 gene shapes the zebrafish neurocranium by regulating frontonasal neural crest cell differentiation timing. Development (Cambridge, England). 148(7):
Tessadori, F., de Bakker, D.E.M., Barske, L., Nelson, N., Algra, H.A., Willekers, S., Nichols, J.T., Crump, J.G., Bakkers, J. (2020) Zebrafish prrx1a mutants have normal hearts. Nature. 585:E14-E16
Kimmel, C.B., Wind, A.L., Oliva, W., Ahlquist, S.D., Walker, C., Dowd, J., Blanco-Sánchez, B., Titus, T.A., Batzel, P., Talbot, J.C., Postlethwait, J.H., Nichols, J.T. (2020) Transgene-mediated skeletal phenotypic variation in zebrafish. Journal of Fish Biology. 98(4):956-970
Sucharov, J., Ray, K., Brooks, E.P., Nichols, J.T. (2019) Selective breeding modifies mef2ca mutant incomplete penetrance by tuning the opposing Notch pathway. PLoS Genetics. 15:e1008507
Brooks, E.P., Nichols, J.T. (2017) Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing. Journal of visualized experiments : JoVE. (127)
Nichols, J.T., Blanco-Sánchez, B., Brooks, E.P., Parthasarathy, R., Dowd, J., Subramanian, A., Nachtrab, G., Poss, K.D., Schilling, T.F., Kimmel, C.B. (2016) Ligament versus bone cell identity in the zebrafish hyoid skeleton is regulated by mef2ca. Development (Cambridge, England). 143(23):4430-4440
Talbot, J.C., Nichols, J.T., Yan, Y.L., Leonard, I.F., BreMiller, R.A., Amacher, S.L., Postlethwait, J.H., Kimmel, C.B. (2016) Pharyngeal morphogenesis requires fras1-itga8- dependent epithelial-mesenchymal interaction. Developmental Biology. 416(1):136-48
Barske, L., Askary, A., Zuniga, E., Balczerski, B., Bump, P., Nichols, J.T., Crump, J.G. (2016) Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genetics. 12:e1005967
Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813
Delaurier, A., Huycke, T.R., Nichols, J.T., Swartz, M.E., Larsen, A., Walker, C., Dowd, J., Pan, L., Moens, C.B., and Kimmel, C.B. (2014) Role of mef2ca in developmental buffering of the zebrafish larval hyoid dermal skeleton. Developmental Biology. 385(2):189-99
Nichols, J.T., Pan, L., Moens, C.B., and Kimmel, C.B. (2013) barx1 represses joints and promotes cartilage in the craniofacial skeleton. Development (Cambridge, England). 140(13):2765-2775
Sasaki, M.M., Nichols, J.T., and Kimmel, C.B. (2013) edn1 and hand2 Interact in Early Regulation of Pharyngeal Arch Outgrowth during Zebrafish Development. PLoS One. 8(6):e67522
Eames, B.F., Delaurier, A., Ullmann, B., Huycke, T.R., Nichols, J.T., Dowd, J., McFadden, M., Sasaki, M.M., and Kimmel, C.B. (2013) FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution. BMC Developmental Biology. 13(1):23

Charles B. Kimmel, Sawyer Watson, Ryan B. Couture, Natasha S. McKibben, James T. Nichols, Shannon E. Richardson and David L. G. Noakes. Patterns of variation and covariation in the shapes of mandibular bones of juvenile salmonids in the genus Oncorhynchus. Evolution & Development. 2015

James T. Nichols, Gerry Weinmaster. Proteolytic activation of Notch signaling: Roles for ligand endocytosis and mechanotransduction (Book Chapter). Handbook of Cell Signaling. 2008

James T. Nichols, Alison Miyamoto, Gerry Weinmaster. Notch Signaling-constantly on the move (Review). Traffic. 2007 Aug 8; (8):959-69.

James T. Nichols, Alison Miyamoto, Samantha L. Olsen, Brendan D’Souza, Christine Yao, and Gerry Weinmaster. DSL-ligand Endocytosis Physically Dissociates Notch1 Heterodimers Before Activating Proteolysis Can Occur. Journal of Cell Biology. 2007 Feb 12; 176(4):445-58.

Ena Ladi, James T. Nichols, Alison Miyamoto, Jim Boulter, Weihong Ge, Liang-Tung Yang, Yi E. Sun, Chris Kintner and Gerry Weinmaster. The Divergent DSL Ligand Dll3 Cannot Activate Notch Signaling but Cell Autonomously Attenuates Signaling Induced by Other DSL Ligands. Journal of Cell Biology. 2005 Sep 12;170(6):983-92.

T Haritunians, T Chow, R P J De Lange, James T. Nichols, D Ghavimi, N Dorrani, D M St Clair, G Weinmaster, C Schanen. Functional analysis of a recurrent missense mutation in Notch3 in CADASIL. Journal of Neurology, Neurosurgery, and Psychiatry. 2005 Sep;76(9):1242-8

Liang-Tung Yang, James T. Nichols, Christine Yao, Jennifer O. Manilay, Ellen A. Robey, and Gerry Weinmaster. Fringe Glycosyltransferases Differentially Modulate Notch1 Proteolysis Induced by Delta1 and Jagged1. Molecular Biology of the Cell. 2005 Feb;16(2):927-42.