| ZFIN ID: ZDB-PUB-190207-6 |
Ectopically Expressed IL-34 Can Efficiently Induce Macrophage Migration to the Liver in Zebrafish
Jiang, Y., Chen, J., Yen, K., Xu, J.
| Date: | 2019 |
|---|---|
| Source: | Zebrafish 16(2): 165-170 (Journal) |
| Registered Authors: | Chen, Jiahao, Jiang, Yunyun, Xu, Jin |
| Keywords: | IL-34, macrophage, migration, zebrafish |
| MeSH Terms: |
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| PubMed: | 30724719 Full text @ Zebrafish |
Citation
Jiang, Y., Chen, J., Yen, K., Xu, J. (2019) Ectopically Expressed IL-34 Can Efficiently Induce Macrophage Migration to the Liver in Zebrafish. Zebrafish. 16(2):165-170.
ABSTRACT
Interleukin-34 (IL-34) is a known cytokine that plays an important role in the survival, proliferation, and differentiation of macrophages. In previous studies, IL-34 can induce macrophage migration through syndecan-1 or focal adhesion kinase and extracellular signal-related kinase 1 and 2 pathway. These studies mainly focused on in vitro experiments, but the effect of IL-34 on macrophage migration in vivo is less understood. In our study, we artificially induced macrophage, but not neutrophil, enrichment in the skin or liver by overexpressing IL-34 in epidermal cells or hepatocytes in zebrafish. Live imaging showed that the enrichment of macrophages in the liver is due to the direct attraction of macrophages by IL-34. Our results demonstrated that ectopically expressed IL-34 can induce macrophage migration to liver in vivo.
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