ZFIN Morpholino: MO1-rac2

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-rac2

No data available

Phenotype

Phenotype resulting from MO1-rac2

Phenotype	Fish	Figures
neutrophil spatial pattern, abnormal	WT + MO1-rac2	Fig. 4 from Deng et al., 2011
neutrophil homeostasis disrupted, abnormal	WT + MO1-rac2	Fig. 4 from Deng et al., 2011

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Phenotype of all Fish created by or utilizing MO1-rac2

Phenotype	Fish	Conditions	Figures
response to fungus process quality, abnormal	AB + MO1-rac2	fungal treatment by injection: Aspergillus fumigatus	Fig 1 from Tanner et al., 2024
defense response to Gram-negative bacterium disrupted, abnormal	WT + MO1-rac2	bacterial treatment by injection: Pseudomonas aeruginosa	Fig. 2 from Deng et al., 2011
neutrophil mediated immunity disrupted, abnormal	WT + MO1-rac2	bacterial treatment by injection: Pseudomonas aeruginosa	Fig. 2 from Deng et al., 2011
neutrophil chemotaxis disrupted, abnormal	WT + MO1-rac2	physical alteration: caudal fin	Fig. 1 from Deng et al., 2011
neutrophil spatial pattern, abnormal	WT + MO1-rac2	standard conditions	Fig. 4 from Deng et al., 2011

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Citations

Include unpublished citations

Tanner, C.D., Rosowski, E.E. (2024) Macrophages inhibit extracellular hyphal growth of A. fumigatus through Rac2 GTPase signaling. Infection and Immunity. 92(2):e0038023
Lu, X., Zhang, Y., Liu, F., Wang, L. (2020) Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus during Zebrafish Embryogenesis. Journal of immunology (Baltimore, Md. : 1950). 204(9):2447-2454
Zhou, W., Pal, A.S., Hsu, A.Y., Gurol, T., Zhu, X., Wirbisky-Hershberger, S.E., Freeman, J.L., Kasinski, A.L., Deng, Q. (2018) MicroRNA-223 Suppresses the Canonical NF-κB Pathway in Basal Keratinocytes to Dampen Neutrophilic Inflammation. Cell Reports. 22:1810-1823
Knox, B.P., Deng, Q., Rood, M., Eickhoff, J.C., Keller, N.P., Huttenlocher, A. (2014) Distinct Innate Immune Phagocyte Responses to Aspergillus fumigatus Conidia and Hyphae in Zebrafish Larvae. Eukaryotic Cell. 13(10):1266-77
Yoo, S.K., Lam, P.Y., Eichelberg, M.R., Zasadil, L., Bement, W.M., and Huttenlocher, A. (2012) The role of microtubules in neutrophil polarity and migration in live zebrafish. Journal of Cell Science. 125(23):5702-5710
Deng, Q., Yoo, S.K., Cavnar, P.J., Green, J.M., and Huttenlocher, A. (2011) Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue. Developmental Cell. 21(4):735-745

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