ZFIN Morpholino: MO4-tnfa

Target Location

Genome Build: GRCz11Chromosome: 19

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-tnfa

No data available

Phenotype

Phenotype resulting from MO4-tnfa

Phenotype	Fish	Figures
caudal hematopoietic tissue hematopoietic multipotent progenitor cell EGFP expression absent, abnormal	la2Tg; sd2Tg + MO4-tnfa	Fig. 2 from Espín-Palazón et al., 2014
caudal hematopoietic tissue hematopoietic multipotent progenitor cell decreased amount, abnormal	la2Tg; sd2Tg + MO4-tnfa	Fig. 2 from Espín-Palazón et al., 2014
dorsal root ganglion peripheral nervous system axon ensheathment decreased occurrence, abnormal	w9Tg + MO4-tnfa	Fig. 4 from Smith et al., 2017
glial cell EGFP expression absent, abnormal	nc1Tg + MO4-tnfa	Fig. 5 from Smith et al., 2017
glial cell Eos expression decreased amount, abnormal	w9Tg + MO4-tnfa	Fig. 4 from Smith et al., 2017

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Phenotype of all Fish created by or utilizing MO4-tnfa

Phenotype	Fish	Conditions	Figures
inflammatory response to antigenic stimulus process quality, abnormal	AB + MO4-tnfa	bacterial treatment: Mycobacterium marinum	Fig. 4 from Tobin et al., 2012
whole organism life span, ameliorated	AB + MO4-tnfa	viral treatment by exposure to environment: Sprivivirus cyprinus	Fig. 1 from Espín-Palazón et al., 2016
defense response to bacterium disrupted, abnormal	AB + MO4-tnfa	bacterial treatment: Mycobacterium marinum	Fig. 4 from Tobin et al., 2012
ventral wall of dorsal aorta myb expression decreased distribution, abnormal	WT + MO4-tnfa	standard conditions	Fig. 1 from Espín-Palazón et al., 2014
T cell rag1 expression absent, abnormal	WT + MO4-tnfa	standard conditions	Fig. 1 from Espín-Palazón et al., 2014

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Citations

Include unpublished citations

Tie, R., Li, H., Cai, S., Liang, Z., Shan, W., Wang, B., Tan, Y., Zheng, W., Huang, H. (2019) Interleukin-6 signaling regulates hematopoietic stem cell emergence. Experimental & molecular medicine. 51:1-12
Hall, C.J., Sanderson, L.E., Lawrence, L.M., Pool, B., van der Kroef, M., Ashimbayeva, E., Britto, D., Harper, J.L., Lieschke, G.J., Astin, J.W., Crosier, K.E., Dalbeth, N., Crosier, P.S. (2018) Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. The Journal of Clinical Investigation. 128(5):1752-1771
Smith, C.J., Wheeler, M.A., Marjoram, L., Bagnat, M., Deppmann, C.D., Kucenas, S. (2017) TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. PLoS Genetics. 13:e1006712
van der Vaart, M., Svoboda, O., Weijts, B.G., Espín-Palazón, R., Sapp, V., Pietri, T., Bagnat, M., Muotri, A.R., Traver, D. (2017) Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.. Disease models & mechanisms. 10(12):1439-1451
Espín-Palazón, R., Martínez-López, A., Roca, F.J., López-Muñoz, A., Tyrkalska, S.D., Candel, S., García-Moreno, D., Falco, A., Meseguer, J., Estepa, A., Mulero, V. (2016) TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS pathogens. 12:e1005699
Marjoram, L., Alvers, A., Deerhake, M.E., Bagwell, J., Mankiewicz, J., Cocchiaro, J.L., Beerman, R.W., Willer, J., Sumigray, K.D., Katsanis, N., Tobin, D.M., Rawls, J.F., Goll, M.G., Bagnat, M. (2015) Epigenetic control of intestinal barrier function and inflammation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(9):2770-5
Candel, S., de Oliveira, S., López-Muñoz, A., García-Moreno, D., Espín-Palazón, R., Tyrkalska, S.D., Cayuela, M.L., Renshaw, S.A., Corbalán-Vélez, R., Vidal-Abarca, I., Tsai, H.J., Meseguer, J., Sepulcre, M.P., Mulero, V. (2014) Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. PLoS Biology. 12:e1001855
Espín-Palazón, R., Stachura, D.L., Campbell, C.A., García-Moreno, D., Del Cid, N., Kim, A.D., Candel, S., Meseguer, J., Mulero, V., Traver, D. (2014) Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 159:1070-85
Tobin, D.M., Roca, F.J., Oh, S.F., McFarland, R., Vickery, T.W., Ray, J.P., Ko, D.C., Zou, Y., Bang, N.D., Chau, T.T., Vary, J.C., Hawn, T.R., Dunstan, S.J., Farrar, J.J., Thwaites, G.E., King, M.C., Serhan, C.N., and Ramakrishnan, L. (2012) Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 148(3):434-446
López-Muñoz, A., Sepulcre, M.P., Roca, F.J., Figueras, A., Meseguer, J., and Mulero, V. (2011) Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis. Molecular immunology. 48(9-10):1073-1083

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