tnfa

ID

ZDB-GENE-050317-1

Name

tumor necrosis factor a (TNF superfamily, member 2)

Symbol

tnfa Nomenclature History

Previous Names

TNF1 (1)
TNF-alpha 1 (1)
tnf-alpha

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including fin regeneration; intestinal epithelial structure maintenance; and response to bacterium. Is active in extracellular space. Is expressed in several structures, including central nervous system; digestive system; eye; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to several human genes including LTA (lymphotoxin alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

277 figures from 217 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnfa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asthma	Alliance	{Asthma, susceptibility to}	600807
immunodeficiency 127	Alliance	?Immunodeficiency 127	620977
migraine	Alliance	{Migraine without aura, susceptibility to}	157300
		{Dementia, vascular, susceptibility to}
		{Malaria, cerebral, susceptibility to}	611162
		{Septic shock, susceptibility to}

Associated With tnfa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006052	Tumour necrosis factor domain
Family	IPR002960	Lymphotoxin-alpha
Family	IPR006053	Tumour necrosis factor
Homologous_superfamily	IPR008983	Tumour necrosis factor-like domain superfamily