ZFIN Morpholino: MO1-llgl1

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-llgl1

No data available

Phenotype

Phenotype resulting from MO1-llgl1

Phenotype	Fish	Figures
brain decreased size, abnormal	WT + MO1-llgl1 + MO4-tp53	Fig. S1 from Clark et al., 2012
cardiac muscle cell hypertrophic, abnormal	WT + MO1-llgl1	Fig. 3 from Flinn et al., 2020
cardiac muscle cell intercalated disc morphology, abnormal	WT + MO1-llgl1	Fig. S7 from Flinn et al., 2020
cardiac muscle cell sarcomere decreased amount, abnormal	WT + MO1-llgl1	Fig. S7 from Flinn et al., 2020
cardiac ventricle morphology, abnormal	WT + MO1-llgl1	Fig. S5 from Flinn et al., 2020

1 - 5 of 37 Show all

Phenotype of all Fish created by or utilizing MO1-llgl1

Phenotype	Fish	Conditions	Figures
peridermal cell actin-based cell projection decreased length, abnormal	TU + MO1-llgl1	standard conditions	Fig. S2 from Magre et al., 2019 Fig. 3 , Fig. 8 from Raman et al., 2016
peridermal cell apical side ab1-llgl2 labeling decreased amount, abnormal	TU + MO1-llgl1	control	Fig. 3 from Raman et al., 2016
peridermal cell actin-based cell projection decreased size, abnormal	TU + MO1-llgl1	standard conditions	Fig. 5 from Raman et al., 2016
peridermal cell actin-based cell projection ab1-llgl2 labeling decreased amount, abnormal	TU + MO1-llgl1	control	Fig. 3 from Raman et al., 2016
heart ccn2a expression decreased amount, abnormal	WT + MO1-llgl1	standard conditions	Fig. 6 from Flinn et al., 2020

1 - 5 of 42 Show all

Citations

Include unpublished citations

Flinn, M.A., Otten, C., Brandt, Z.J., Bostrom, J.R., Kenarsary, A., Wan, T.C., Auchampach, J.A., Abdelilah-Seyfried, S., O'Meara, C.C., Link, B.A. (2020) Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes. Development (Cambridge, England). 147(16):
Magre, I., Fandade, V., Damle, I., Banerjee, P., Yadav, S.K., Sonawane, M., Joseph, J. (2019) Nup358 regulates microridge length by controlling SUMOylation-dependent activity of aPKC in zebrafish epidermis. Journal of Cell Science. 132(12):
Raman, R., Damle, I., Rote, R., Banerjee, S., Dingare, C., Sonawane, M. (2016) aPKC regulates apical localization of Lgl to restrict elongation of microridges in developing zebrafish epidermis. Nature communications. 7:11643
Clark, B.S., Cui, S., Miesfeld, J.B., Klezovitch, O., Vasioukhin, V., and Link, B.A. (2012) Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. Development (Cambridge, England). 139(9):1599-1610
Hava, D., Forster, U., Matsuda, M., Cui, S., Link, B.A., Eichhorst, J., Wiesner, B., Chitnis, A., and Abdelilah-Seyfried, S. (2009) Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. Journal of Cell Science. 122(Pt 5):687-695

1 - 5 of 5

Show