ZFIN Morpholino: MO1-wnt11f2

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-wnt11f2

No data available

Phenotype

Phenotype resulting from MO1-wnt11f2

Phenotype	Fish	Figures
axis decreased length, abnormal	WT + MO1-wnt11f2	Fig. 9 , Fig. S3 from Goudevenou et al., 2011 Fig. 6 from Zhu et al., 2006
brain morphology, abnormal	WT + MO1-wnt11f2	Fig. 9 from Goudevenou et al., 2011
cell migration involved in gastrulation decreased rate, abnormal	WT + MO1-wnt11f2	Fig. 6 from van Eekelen et al., 2010
cell migration involved in gastrulation disrupted, abnormal	WT + MO1-wnt11f2	Fig. 9 from Goudevenou et al., 2011
convergent extension disrupted, abnormal	WT + MO1-wnt11f2	Fig. 6 from Ferrante et al., 2009 Fig. 2 from Lemeer et al., 2007

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Phenotype of all Fish created by or utilizing MO1-wnt11f2

Phenotype	Fish	Conditions	Figures
whole organism anterior-posterior axis decreased length, abnormal	WT + MO1-wnt11f2	standard conditions	Fig. 6 from Xu et al., 2014 Fig. 1 from Jopling et al., 2005
whole organism anterior-most region increased angle to whole organism posterior-most region, abnormal	WT + MO1-wnt11f2	standard conditions	Fig. 6 from Xu et al., 2014
eye decreased distance eye, abnormal	WT + MO1-wnt11f2	standard conditions	Fig. 2 from Macheda et al., 2012 Fig. 9 from Goudevenou et al., 2011
brain morphology, abnormal	WT + MO1-wnt11f2	standard conditions	Fig. 9 from Goudevenou et al., 2011
cell migration involved in gastrulation disrupted, abnormal	WT + MO1-wnt11f2	standard conditions	Fig. 9 from Goudevenou et al., 2011

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Citations

Include unpublished citations

McLeod, J.J., Rothschild, S.C., Francescatto, L., Kim, H., Tombes, R.M. (2023) Specific CaMKIIs mediate convergent extension cell movements in early zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(4):390-403
Smutny, M., Ákos, Z., Grigolon, S., Shamipour, S., Ruprecht, V., Čapek, D., Behrndt, M., Papusheva, E., Tada, M., Hof, B., Vicsek, T., Salbreux, G., Heisenberg, C.P. (2017) Friction forces position the neural anlage. Nature cell biology. 19(4):306-317
Fang, X., Zhang, B., Thisse, B., Bloom, G.S., Thisse, C. (2015) IQGAP3 Is Essential for Cell Proliferation and Motility During Zebrafish Embryonic Development. Cytoskeleton (Hoboken, N.J.). 72(8):422-33
Wu, B.T., Wen, S.H., Hwang, S.P., Huang, C.J., Kuan, Y.S. (2015) Control of Wnt5b secretion by wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression. Journal of Cell Science. 128(12):2328-39
Xu, X., Shuen, W.H., Chen, C., Goudevenou, K., Jones, P., and Sablitzky, F. (2014) Swap70b is required for convergent and extension cell movement during zebrafish gastrulation linking Wnt11 signalling and RhoA effector function. Developmental Biology. 386(1):191-203
Chen, Q., Takada, R., and Takada, S. (2012) Loss of Porcupine impairs convergent extension during gastrulation in zebrafish. Journal of Cell Science. 125(9):2224-2234
Macheda, M.L., Sun, W.W., Kugathasan, K., Hogan, B.M., Bower, N.I., Halford, M.M., Zhang, Y.F., Jacques, B.E., Lieschke, G.J., Dabdoub, A., and Stacker, S.A. (2012) The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling. The Journal of biological chemistry. 287(35):29312-29323
Clements, W.K., Kim, A.D., Ong, K.G., Moore, J.C., Lawson, N.D., and Traver, D. (2011) A somitic Wnt16/Notch pathway specifies haematopoietic stem cells. Nature. 474(7350):220-224
Fischer, S., Filipek-Gorniok, B., and Ledin, J. (2011) Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling. BMC Developmental Biology. 11(1):53
Goudevenou, K., Martin, P., Yeh, Y.J., Jones, P., and Sablitzky, F. (2011) Def6 Is Required for Convergent Extension Movements during Zebrafish Gastrulation Downstream of Wnt5b Signaling. PLoS One. 6(10):e26548

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