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Fig. 7
miR-27b depletion induces weight gain and increases fat mass in adult bC7aSPs. (A) bC27bSPs, hC27bSPs and WT were fed a HFD for 210 days. Serial body weight of each zebrafish was monitored monthly (n = 20–25). * p < 0.01, and ** p < 0.005. (B) Representative images of male and female bC27bSP1 and WT fed either a HFD for five months. (C) miR-27b depletion leads to greater abdominal fat (left), larger internal organs (middle) and the increased intra-abdominal fat pad size is shown (right). Adipose tissues are circled. 40× magnification, scale bars: 25 mm (D) Expression of adipogenic genes and proteins in abdominal fat of WT and bC27bSP1. PPAR-γ, C/EBP-β, and SREBP-1c mRNA (left, qRT-PCR) and proteins (right, western blot). * p < 0.01, and ** p < 0.005.
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