Gene
cebpa
- ID
- ZDB-GENE-020111-2
- Name
- CCAAT enhancer binding protein alpha
- Symbol
- cebpa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including hematopoietic stem cell migration; hemopoiesis; and negative regulation of macrophage differentiation. Predicted to be located in nucleus. Is expressed in several structures, including adipose tissue; digestive system; hematopoietic cell; hematopoietic system; and mesoderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CEBPA (CCAAT enhancer binding protein alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 66 figures from 51 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1062 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute myeloid leukemia | Alliance | Leukemia, acute myeloid, somatic | 601626 |
| acute myeloid leukemia | Alliance | ?Leukemia, acute myeloid | 601626 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Basic-leucine zipper domain | Basic-leucine zipper domain superfamily | CCAAT/enhancer-binding protein C/EBP | CCAAT/enhancer-binding protein, chordates |
|---|---|---|---|---|---|---|
| UniProtKB:Q8UVZ1 | InterPro | 288 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
- Deebani, A., Mary, J., Dhinoja, S., Al Qaryoute, A., Fallatah, W., Jagadeeswaran, P. (2025) Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition. Scientific Reports. 15:30583058
- Doll, L., Welte, K., Skokowa, J., Bajoghli, B. (2024) A JAGN1-associated severe congenital neutropenia zebrafish model revealed an altered G-CSFR signaling and UPR activation. Blood advances. 8(15):4050-4065
- Gimenez, G., Kalev-Zylinska, M.L., Morison, I., Bohlander, S.K., Horsfield, J.A., Antony, J. (2024) Cohesin rad21 mutation dysregulates erythropoiesis and granulopoiesis output within the whole kidney marrow of adult zebrafish. American journal of physiology. Cell physiology. 328(1):C9-C19
- Guggeri, L., Sosa-Redaelli, I., Cárdenas-Rodríguez, M., Alonso, M., González, G., Naya, H., Prieto-Echagüe, V., Lepanto, P., Badano, J.L. (2024) Follistatin like-1 (Fstl1) regulates adipose tissue development in zebrafish. Adipocyte. 13:24358622435862
- Hu, Y., Luo, Z., Wang, M., Wu, Z., Liu, Y., Cheng, Z., Sun, Y., Xiong, J.W., Tong, X., Zhu, Z., Zhang, B. (2024) Prox1a promotes liver growth and differentiation by repressing cdx1b expression and intestinal fate transition in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 52(1):66-77
- Lin, B., Wan, H., Yang, J., Yu, L., Zhou, H., Wan, H. (2024) Lipid regulation of protocatechualdehyde and hydroxysafflor yellow A via AMPK/SREBP2/PCSK9/LDLR signaling pathway in hyperlipidemic zebrafish. Heliyon. 10:e24908e24908
- Lints, R., Walker, C.A., Delfi, O., Prouse, M., De Silva, M.P., Bohlander, S.K., Wood, A.C. (2024) Mutational cooperativity of RUNX1::RUNX1T1 isoform 9a and oncogenic NRAS in zebrafish myeloid leukaemia. Biology Open. 13(9):
- Luo, H., Li, Q., Hong, J., Huang, Z., Deng, W., Wei, K., Lu, S., Wang, H., Zhang, W., Liu, W. (2024) Targeting TNF/IL-17/MAPK pathway in hE2A-PBX1 leukemia: effects of OUL35, KJ-Pyr-9, and CID44216842. Haematologica. 109(7):2092-2110
- Tian, Y., Lautrup, S., Law, P.W.N., Dinh, N.D., Fang, E.F., Chan, W.Y. (2024) WRN loss accelerates abnormal adipocyte metabolism in Werner syndrome. Cell & Bioscience. 14:77
- Wang, X., Li, X., Wang, Y., Ren, Z., Du, X., Gao, J., Ji, G., Liu, Z. (2024) Nkx1.2 deletion decreases fat production in zebrafish. Obesity (Silver Spring, Md.). 32(7):1315-1328
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