ZFIN Image: Drummond et al., 2013, Fig. 6

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Fig. 6

Hindbrain patterning in Zic morpholino-injected embryos. mRNA expression of hindbrain segmentation markers hoxa2b/aldh1a2(A, B), krox20/hoxb4a/wnt1(C, D), hoxb1a(E,F), mafba/wnt1(G, H), and egfl6(I-L) were examined in control uninjected (A, C, E, G, I, J) and Zic2a;Zic2b;Zic3MO-injected embryos (B, D, F, H, K, L). We note a reduction in hoxa2b expression in Zic morphant embryos (compare B to A) as well as a thinning of rhombomeres 3 and 5, as labeled by krox20 expression (compare D to C). Expression of hoxb4a is reduced (compare D to C), but other markers of segment identity are overtly normal (E-L). Embryos are shown in dorsal (A-H, J, L) or lateral (I, K) views and are 18 hpf.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.