egr2b

ID

ZDB-GENE-980526-283

Name

early growth response 2b

Symbol

egr2b Nomenclature History

Previous Names

egr2 (1)
cb427 (1)
id:ibd5073 (1)
krox-20
krox20
krx20
wu:fb71h10
zgc:92210

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryonic organ development and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including nervous system; neural crest; neural keel; neural plate; and neural rod. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

562 figures from 389 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb427 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With egr2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease type 1D	Alliance	Charcot-Marie-Tooth disease, type 1D	607678
Charcot-Marie-Tooth disease type 3	Alliance	Dejerine-Sottas disease	145900
Charcot-Marie-Tooth disease type 4E	Alliance	Hypomyelinating neuropathy, congenital, 1	605253