Gene

egr2b

ID
ZDB-GENE-980526-283
Name
early growth response 2b
Symbol
egr2b Nomenclature History
Previous Names
  • egr2 (1)
  • cb427 (1)
  • id:ibd5073 (1)
  • krox-20
  • krox20
  • krx20
  • wu:fb71h10
  • zgc:92210
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic organ development and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including nervous system; neural crest; neural keel; neural plate; and neural rod. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
545 figures from 378 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egr2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 1D Alliance Charcot-Marie-Tooth disease, type 1D 607678
Charcot-Marie-Tooth disease type 3 Alliance Dejerine-Sottas disease 145900
Charcot-Marie-Tooth disease type 4E Alliance Hypomyelinating neuropathy, congenital, 1 605253
Associated With egr2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Domain IPR021849 Early growth response, N-terminal
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Early growth response, N-terminal Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:E9QC39 232
UniProtKB:Q66HY5 412
UniProtKB:Q05159 412
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations