Gene

egfl6

ID
ZDB-GENE-040718-157
Name
EGF-like-domain, multiple 6
Symbol
egfl6 Nomenclature History
Previous Names
  • cb3 (1)
  • maeg (1)
  • sb:cb3
  • wu:fc66b04
  • zgc:92328
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Enables integrin binding activity and receptor ligand activity. Involved in positive regulation of cell migration involved in sprouting angiogenesis and regulation of sprouting angiogenesis. Acts upstream of or within several processes, including intracellular signal transduction; positive regulation of sprouting angiogenesis; and regulation of Notch signaling pathway. Predicted to be located in membrane. Is expressed in several structures, including fin; median fin fold; pharyngeal arch; rhombomere; and somite. Orthologous to human EGFL6 (EGF like domain multiple 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egfl6 Human Ortholog
No data available
Associated With egfl6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000998 MAM domain
Domain IPR001881 EGF-like calcium-binding domain
Family IPR032930 Epidermal growth factor-like protein 6
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Epidermal growth factor-like protein 6 Growth factor receptor cysteine-rich domain superfamily MAM domain
UniProtKB:Q6DHG1 508
UniProtKB:A0A0R4IZW3 35
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-egfl6 monoclonal Mouse
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations