Gene
aldh1a2
- ID
- ZDB-GENE-011010-3
- Name
- aldehyde dehydrogenase 1 family, member A2
- Symbol
- aldh1a2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable aldehyde dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including chordate embryonic development; myelination; and tube morphogenesis. Is expressed in several structures, including head; heart; immature eye; mesoderm; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 137 figures from 105 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 40 figures from 24 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Diaphragmatic hernia 4, with cardiovascular defects | 620025 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| Conserved_site | IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| Domain | IPR015590 | Aldehyde dehydrogenase domain |
| Homologous_superfamily | IPR016161 | Aldehyde/histidinol dehydrogenase |
| Homologous_superfamily | IPR016162 | Aldehyde dehydrogenase, N-terminal |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Aldehyde dehydrogenase, C-terminal | Aldehyde dehydrogenase, cysteine active site | Aldehyde dehydrogenase domain | Aldehyde dehydrogenase, glutamic acid active site | Aldehyde dehydrogenase, N-terminal | Aldehyde/histidinol dehydrogenase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q90XS8 | InterPro | 518 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
aldh1a2-201
(1)
|
Ensembl | 3,252 nt | ||
| ncRNA |
aldh1a2-002
(1)
|
Ensembl | 699 nt |
1 - 2 of 2
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-aldh1a2 | polyclonal | IgG | Rabbit |
|
GeneTex
|
24 |
1 - 1 of 1
Plasmids
No data available