ZFIN is now using GRCz12tu for Genomic Data
Gene
en1b
- ID
- ZDB-GENE-980526-6
- Name
- engrailed homeobox 1b
- Symbol
- en1b Nomenclature History
- Previous Names
-
- eng1b
- eng4
- engrailed 4
- wu:fc84e11
- zgc:113499
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within axonogenesis involved in innervation and neuron fate commitment. Predicted to be located in nucleus. Is expressed in midbrain hindbrain boundary neural keel; myoseptum; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease and disease of mental health. Orthologous to human EN1 (engrailed homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138514 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?ENDOVE syndrome, limb-brain type | 619218 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Conserved_site | IPR019737 | Homeobox engrailed-type, conserved site |
| Domain | IPR000747 | Homeodomain engrailed |
| Domain | IPR001356 | Homeodomain |
| Domain | IPR019549 | Homeobox engrailed, C-terminal |
| Domain | IPR020479 | Homeodomain, metazoa |
| Family | IPR050720 | Engrailed Homeobox Transcription Factors |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Engrailed Homeobox Transcription Factors | Homedomain-like superfamily | Homeobox, conserved site | Homeobox engrailed, C-terminal | Homeobox engrailed-type, conserved site | Homeodomain | Homeodomain engrailed | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B3Y5 | InterPro | 278 | ||||||||
| UniProtKB:Q5BJ08 | InterPro | 274 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers