Gene
en1b
- ID
- ZDB-GENE-980526-6
- Name
- engrailed homeobox 1b
- Symbol
- en1b Nomenclature History
- Previous Names
-
- eng1b
- eng4
- engrailed 4
- wu:fc84e11
- zgc:113499
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within axonogenesis involved in innervation and neuron fate commitment. Is expressed in myoseptum; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138514 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
?ENDOVE syndrome, limb-brain type | 619218 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017970 | Homeobox, conserved site |
Conserved_site | IPR019737 | Homeobox engrailed-type, conserved site |
Domain | IPR000747 | Homeobox domain engrailed |
Domain | IPR001356 | Homeobox domain |
Domain | IPR019549 | Homeobox engrailed, C-terminal |
Domain | IPR020479 | Homeobox domain, metazoa |
Homologous_superfamily | IPR009057 | Homeobox-like domain superfamily |
Domain Details Per Protein
Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox domain engrailed | Homeobox domain, metazoa | Homeobox engrailed, C-terminal | Homeobox engrailed-type, conserved site | Homeobox-like domain superfamily |
---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0R4IKF8
|
168 | |||||||
UniProtKB:Q9YGU2
|
259 | |||||||
UniProtKB:Q5BJ08
|
274 |
Interactions and Pathways
No data available
Plasmids
No data available