Gene

en1b

ID

ZDB-GENE-980526-6

Name

engrailed homeobox 1b

Symbol

en1b Nomenclature History

Previous Names

eng1b
eng4
engrailed 4
wu:fc84e11
zgc:113499

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within axonogenesis involved in innervation and neuron fate commitment. Is expressed in myoseptum; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 13 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7138514 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With en1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?ENDOVE syndrome, limb-brain type	619218

Associated With en1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Conserved_site	IPR019737	Homeobox engrailed-type, conserved site
Domain	IPR000747	Homeobox domain engrailed
Domain	IPR001356	Homeobox domain
Domain	IPR019549	Homeobox engrailed, C-terminal
Domain	IPR020479	Homeobox domain, metazoa
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily