Gene
en1a
- ID
- ZDB-GENE-980526-216
- Name
- engrailed homeobox 1a
- Symbol
- en1a Nomenclature History
- Previous Names
-
- en-1
- en1
- eng1 (1)
- eng1a
- zgc:100771
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within axonogenesis involved in innervation. Is expressed in several structures, including adaxial cell; midbrain hindbrain boundary neural rod; musculature system; pectoral fin bud; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 25 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138684 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?ENDOVE syndrome, limb-brain type | 619218 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR000047 | Helix-turn-helix motif |
| Conserved_site | IPR017970 | Homeobox, conserved site |
| Conserved_site | IPR019737 | Homeobox engrailed-type, conserved site |
| Domain | IPR000747 | Homeobox domain engrailed |
| Domain | IPR001356 | Homeobox domain |
| Domain | IPR019549 | Homeobox engrailed, C-terminal |
| Domain | IPR020479 | Homeobox domain, metazoa |
| Homologous_superfamily | IPR009057 | Homeobox-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Helix-turn-helix motif | Homeobox, conserved site | Homeobox domain | Homeobox domain engrailed | Homeobox domain, metazoa | Homeobox engrailed, C-terminal | Homeobox engrailed-type, conserved site | Homeobox-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q68EL7
|
231 | ||||||||
|
UniProtKB:Q04896
|
231 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available