Gene

en1a

ID

ZDB-GENE-980526-216

Name

engrailed homeobox 1a

Symbol

en1a Nomenclature History

Previous Names

en-1
en1
eng1 (1)
eng1a
zgc:100771

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have sequence-specific DNA binding activity. Involved in axonogenesis involved in innervation. Predicted to localize to RSC-type complex. Is expressed in several structures, including adaxial cell; midbrain hindbrain boundary neural rod; musculature system; pectoral fin bud; and somite. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

41 figures from 25 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7138684 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With en1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?ENDOVE syndrome, limb-brain type	619218

Associated With en1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Conserved_site	IPR019737	Homeobox engrailed-type, conserved site
Domain	IPR000747	Homeobox domain engrailed
Domain	IPR001356	Homeobox domain
Domain	IPR019549	Homeobox engrailed, C-terminal
Domain	IPR020479	Homeobox domain, metazoa
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily

Domain Details Per Protein

Protein	Length	Helix-turn-helix motif	Homeobox, conserved site	Homeobox domain	Homeobox domain engrailed	Homeobox domain, metazoa	Homeobox engrailed, C-terminal	Homeobox engrailed-type, conserved site	Homeobox-like domain superfamily
UniProtKB:Q68EL7 InterPro	231
UniProtKB:Q04896 InterPro	231

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-eng	monoclonal	en1a en1b en2a en2b	IgG1 , k	Mouse	IHC	Developmental Studies Hybridoma Bank	117

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations