ZFIN is now using GRCz12tu for Genomic Data

Gene

ext2

ID

ZDB-GENE-041124-3

Name

exostosin glycosyltransferase 2

Symbol

ext2 Nomenclature History

Previous Names

ext2a (1)
dackel
dak
fc14g07
wu:fc14g07 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and acetylglucosaminyltransferase activity. Acts upstream of or within several processes, including axon guidance; embryonic morphogenesis; and proteoglycan biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. Is expressed in nervous system and pectoral fin musculature. Used to study hereditary multiple exostoses. Orthologous to human EXT2 (exostosin glycosyltransferase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Lee et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 62 figures from 21 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ext2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary multiple exostoses	Alliance	Exostoses, multiple, type 2	133701
		Seizures, scoliosis, and macrocephaly syndrome	616682

Associated With ext2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
hereditary multiple exostoses	ext2^{to273b/to273b}	standard conditions	Wiweger et al., 2014

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR015338	Glycosyl transferase 64 domain
Domain	IPR040911	Exostosin, GT47 domain
Family	IPR004263	Exostosin-like
Homologous_superfamily	IPR029044	Nucleotide-diphospho-sugar transferases

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:Q5U7A7	InterPro	719
UniProtKB:A0A8M1N3H0	InterPro	719
UniProtKB:A0AB32TX90	InterPro	736

Transcripts

Genome Browsers

NCBI Map Viewer

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ext2-201 (1) Ensembl	Ensembl	3,172 nt	Select Tool ZFIN BLAST
ncRNA	ext2-002 (1) Ensembl	Ensembl	784 nt	Select Tool ZFIN BLAST
ncRNA	ext2-003 (1) Ensembl	Ensembl	667 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations