ZFIN is now using GRCz12tu for Genomic Data
Gene
hsp70l
- ID
- ZDB-GENE-050321-1
- Name
- heat shock cognate 70-kd protein, like
- Symbol
- hsp70l Nomenclature History
- Previous Names
-
- hsp70-4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within several processes, including definitive hemopoiesis; response to cadmium ion; and response to heat. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in lens. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1A (heat shock protein family A (Hsp70) member 1A); and HSPA1B (heat shock protein family A (Hsp70) member 1B).
- Genome Resources
- Note
-
The promoter region of this gene is used in most "hsp70" transgenic lines.
- Comparative Information
-
- All Expression Data
- 25 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018181 | Heat shock protein 70, conserved site |
| Family | IPR013126 | Heat shock protein 70 family |
| Homologous_superfamily | IPR029047 | Heat shock protein 70kD, peptide-binding domain superfamily |
| Homologous_superfamily | IPR029048 | Heat shock protein 70kD, C-terminal domain superfamily |
| Homologous_superfamily | IPR043129 | ATPase, nucleotide binding domain |
Domain Details Per Protein
| Protein | Additional Resources | Length | ATPase, nucleotide binding domain | Heat shock protein 70, conserved site | Heat shock protein 70 family | Heat shock protein 70kD, C-terminal domain superfamily | Heat shock protein 70kD, peptide-binding domain superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:A8WFS0 | InterPro | 643 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
hsp70l-201
(1)
|
Ensembl | 2,302 nt |
Interactions and Pathways
No data available
Plasmids
- Genome Browsers