Gene
xirp2a
- ID
- ZDB-GENE-040108-7
- Name
- xin actin binding repeat containing 2a
- Symbol
- xirp2a Nomenclature History
- Previous Names
-
- xirp2
- sb:cb1045
- wu:fc12g12
- Xin beta6 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be located in anchoring junction. Predicted to colocalize with focal adhesion and stress fiber. Is expressed in several structures, including fin; forebrain; musculature system; pericardial region; and somite. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human XIRP2 (xin actin binding repeat containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 48 figures from 22 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1045 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Actin-binding, Xin repeat | Xin actin-binding repeat-containing protein 1/2 |
|---|---|---|---|---|
| UniProtKB:F8W4U4 | InterPro | 3315 | ||
| UniProtKB:A0A8M3AT61 | InterPro | 3183 | ||
| UniProtKB:A0A8M2BD29 | InterPro | 3314 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
xirp2a-201
(1)
|
Ensembl | 10,784 nt | ||
| mRNA |
xirp2a-202
(1)
|
Ensembl | 4,032 nt | ||
| mRNA |
xirp2a-203
(1)
|
Ensembl | 9,948 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-276L13 | ||
| Encodes | EST | cb1045 | Thisse et al., 2001 | |
| Encodes | EST | fc12g12 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068221888 (1) | 12272 nt | ||
| Genomic | GenBank:BX511272 (1) | 193311 nt | ||
| Polypeptide | UniProtKB:F8W4U4 (1) | 3315 aa |
- Cumplido, N., Arratia, G., Desvignes, T., Muñoz-Sánchez, S., Postlethwait, J.H., Allende, M.L. (2024) Hox genes control homocercal caudal fin development and evolution. Science advances. 10:eadj5991
- Miller, B.M., Goessling, W. (2024) The proteasome subunit psmb1 is essential for craniofacial cartilage maturation and morphogenesis. JCI insight. 9(16):
- Keseroglu, K., Zinani, O.Q.H., Keskin, S., Seawall, H., Alpay, E.E., Özbudak, E.M. (2023) Stochastic gene expression and environmental stressors trigger variable somite segmentation phenotypes. Nature communications. 14:64976497
- Nie, C.H., Wan, S.M., Chen, Y.L., Huysseune, A., Wu, Y.M., Zhou, J.J., Hilsdorf, A.W.S., Wang, W.M., Witten, P.E., Lin, Q., Gao, Z.X. (2022) Single-cell transcriptomes and runx2b-/- mutants reveal the genetic signatures of intermuscular bone formation in zebrafish. National science review. 9:nwac152nwac152
- Simsek, M.F., Chandel, A.S., Saparov, D., Zinani, O.Q.H., Clason, N., Özbudak, E.M. (2022) Periodic inhibition of Erk activity drives sequential somite segmentation. Nature. 613(7942):153-159
- Xu, H., Tong, G., Yan, T., Dong, L., Yang, X., Dou, D., Sun, Z., Liu, T., Zheng, X., Yang, J., Sun, X., Zhou, Y., Kuang, Y. (2022) Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish. Frontiers in cell and developmental biology. 10:821471
- Xue, S., Ly, T.T.N., Vijayakar, R.S., Chen, J., Ng, J., Mathuru, A.S., Magdinier, F., Reversade, B. (2022) HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring. Nature communications. 13:3583
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Uriu, K., Liao, B.K., Oates, A.C., Morelli, L.G. (2021) From local resynchronization to global pattern recovery in the zebrafish segmentation clock. eLIFE. 10:
- Yamada, K., Maeno, A., Araki, S., Kikuchi, M., Suzuki, M., Ishizaka, M., Satoh, K., Akama, K., Kawabe, Y., Suzuki, K., Kobayashi, D., Hamano, N., Kawamura, A. (2021) An atlas of seven zebrafish hox cluster mutants provides insights into sub/neofunctionalization of vertebrate Hox clusters. Development (Cambridge, England). 148(11):
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