PUBLICATION

Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis

Authors
Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D.
ID
ZDB-PUB-220209-6
Date
2022
Source
Communications biology   5: 113 (Journal)
Registered Authors
Bensimon, David, Distel, Martin, Ducos, Bertrand, Vriz, Sophie, Zhang, Weiting
Keywords
none
MeSH Terms
  • Embryo, Nonmammalian/metabolism*
  • Embryonic Development/genetics
  • Embryonic Development/physiology*
  • Animals
  • RNA, Messenger/genetics
  • RNA, Messenger/metabolism
  • p-Aminoazobenzene/analogs & derivatives
  • p-Aminoazobenzene/pharmacology
  • Zebrafish
  • Gene Expression Regulation, Developmental/physiology*
  • Fibroblast Growth Factor 8/genetics
  • Fibroblast Growth Factor 8/metabolism*
(all 12)
PubMed
35132142 Full text @ Commun Biol
Abstract
Somitogenesis, the segmentation of the antero-posterior axis in vertebrates, is thought to result from the interactions between a genetic oscillator and a posterior-moving determination wavefront. The segment (somite) size is set by the product of the oscillator period and the velocity of the determination wavefront. Surprisingly, while the segmentation period can vary by a factor three between 20 °C and 32 °C, the somite size is constant. How this temperature independence is achieved is a mystery that we address in this study. Using RT-qPCR we show that the endogenous fgf8 mRNA concentration decreases during somitogenesis and correlates with the exponent of the shrinking pre-somitic mesoderm (PSM) size. As the temperature decreases, the dynamics of fgf8 and many other gene transcripts, as well as the segmentation frequency and the PSM shortening and tail growth rates slows down as T-Tc (with Tc = 14.4 °C). This behavior characteristic of a system near a critical point may account for the temperature independence of somitogenesis in zebrafish.
Genes / Markers
Figures
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Expression
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
vi1TgTransgenic Insertion
    zf2052TgTransgenic Insertion
      zf3944TgTransgenic Insertion
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        Human Disease / Model
        No data available
        Sequence Targeting Reagents
        No data available
        Fish
        No data available
        Antibodies
        No data available
        Orthology
        No data available
        Engineered Foreign Genes
        Marker Marker Type Name
        CFPEFGCFP
        EosEFGEos
        GAL4EFGGAL4
        KTREFGKTR
        mCloverEFGmClover
        1 - 5 of 5
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        Mapping
        No data available
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        Citation
        Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113.