gpx4b

ID

ZDB-GENE-030410-3

Name

glutathione peroxidase 4b

Symbol

gpx4b Nomenclature History

Previous Names

cb692 (1)
PHGPxb (1)
zgc:110018

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be active in mitochondrion and nucleus. Is expressed in several structures, including alar plate midbrain region; blastoderm; digestive system; musculature system; and visual system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 11 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb692 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gpx4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
spondylometaphyseal dysplasia Sedaghatian type	Alliance	Spondylometaphyseal dysplasia, Sedaghatian type	250220

Associated With gpx4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR029759	Glutathione peroxidase active site
Conserved_site	IPR029760	Glutathione peroxidase conserved site
Family	IPR000889	Glutathione peroxidase
Homologous_superfamily	IPR036249	Thioredoxin-like superfamily