Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish
- Thisse, C., Degrave, A., Kryukov, G.V., Gladyshev, V.N., Obrecht-Pflumio, S., Krol, A., Thisse, B., and Lescure, A.
- Gene expression patterns : GEP 3(4): 525-532 (Journal)
- Registered Authors
- Degrave, Agnes, Gladyshev, Vadim, Krol, Alain, Kryukov, Gregory, Lescure, Alain, Obrecht-Pflumio, Sophie, Thisse, Bernard, Thisse, Christine
- MeSH Terms
- Gene Expression Regulation, Developmental
- In Situ Hybridization
- Molecular Sequence Data
- RNA Probes
- RNA, Messenger/metabolism
- Tissue Distribution
- Zebrafish Proteins
- 12915322 Full text @ Gene Expr. Patterns
Thisse, C., Degrave, A., Kryukov, G.V., Gladyshev, V.N., Obrecht-Pflumio, S., Krol, A., Thisse, B., and Lescure, A. (2003) Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene expression patterns : GEP. 3(4):525-532.
Selenium is important for embryogenesis in vertebrates but little is known about the expression patterns and biological functions of most selenoprotein genes. Taking advantage of the zebrafish model, systematic analysis of selenoprotein gene expression was performed by in situ hybridization on whole-mount embryos at different developmental stages. Twenty-one selenoprotein mRNAs were analyzed and all of them exhibited expression patterns restricted to specific tissues. Moreover, we demonstrated that highly similar selenoprotein paralogs were expressed within distinct territories. Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function.
Genes / Markers
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Engineered Foreign Genes
Errata and Notes