Gene
gpx4a
- ID
- ZDB-GENE-030410-2
- Name
- glutathione peroxidase 4a
- Symbol
- gpx4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Predicted to act upstream of or within response to oxidative stress. Predicted to be active in mitochondrion and nucleus. Is expressed in epidermal superficial stratum; gut; liver; otic vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb563 (7 images)
- cb691 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Mendieta-Serrano et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la022219Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8646 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9384 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylometaphyseal dysplasia Sedaghatian type | Alliance | Spondylometaphyseal dysplasia, Sedaghatian type | 250220 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione peroxidase | Glutathione peroxidase active site | Glutathione peroxidase conserved site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N2T9 | InterPro | 186 | ||||
| UniProtKB:A0A8M1PAF3 | InterPro | 194 |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gpx4 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-243B8 | ZFIN Curated Data | |
| Encodes | EST | cb563 | Thisse et al., 2001 | |
| Encodes | EST | cb691 | Thisse et al., 2001 | |
| Encodes | EST | fb82e03 | ||
| Encodes | cDNA | MGC:92253 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001346537 (1) | 920 nt | ||
| Genomic | GenBank:CU695074 (2) | 101593 nt | ||
| Polypeptide | UniProtKB:A0A8M1PAF3 (1) | 194 aa |
- Khazaei, M., Ardeshir, R.A. (2024) Protective effects of sulfated polysaccharides from Enteromorpha intestinalis on oxidative stress, liver iron overload and Ferroptosis in Zebra fish exposed to ethanol. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 181:117715117715
- Li, X., Li, Y., Xie, A., Chen, F., Wang, J., Zhou, J., Xu, X., Xu, Z., Wang, Y., Qiu, X. (2024) A potent and selective anti-glutathione peroxidase 4 nanobody as a ferroptosis inducer. Chemical science. 15(46):19420-19431
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Zang, X., Wang, Y., Han, C., Cui, L., Liu, H., Tian, S., Liu, K., Li, P., Sun, C., Xia, Q., Zhang, Y. (2024) 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Marine drugs. 22(11):
- Feng, J., Chen, X., Wang, S., Zhang, J., Wang, Q., Guo, S., Shen, Q. (2023) Transcriptomics integrated with metabolomics reveals the ameliorating effect of mussel-derived plasmalogens on high-fat diet-induced hyperlipidemia in zebrafish. Food & function. 14(8):3641-3658
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Wang, L., Yin, J., Liao, C., Cheng, R., Chen, F., Yu, H., Zhang, X. (2023) Selenium deficiency-induced high concentration of ROS restricts hypertrophic growth of skeletal muscle in juvenile zebrafish by suppressing TORC1-mediated protein synthesis. The British journal of nutrition. 130(11):1841-1851
- Wang, Y., Bo, J., Zhao, Z., Han, Y., Zhang, Q., Liu, L. (2023) Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis. Life sciences. 332:122086
- Xu, H., Mao, X., Nie, Z., Li, Y. (2023) Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish. Free radical biology & medicine. 203:102-113
- Yueyue, F., Qin, W., Jigang, L., Ouyang, L., Hu, Q., Chen, L. (2023) New insights into the antimicrobial mechanism of LEAP2 mutant zebrafish under Aeromonas hydrophila infection using transcriptome analysis. Fish & shellfish immunology. 143:109225
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